Pérez-Rodríguez M

Language: Spanish
References: 7
Page: 21-23
PDF size: 134.35 Kb.

ABSTRACT

NK cells can differentiate self from nonself by gauging the expression of HLA class I molecules on autologous cells. Thus, the interaction of MHC class I molecules with KIR receptors, expressed on NK cell surface, prevent NK cells from killing normal cells. However, in haploidentical donor stem cell transplantation some NK cells from the donor may display the ability to kill target cell from the recipient. This alloreactivity function has shown an antileukemia effect, lower incidence of graft rejection, reduce graft versus host disease and decrease leukemia relapses. The KIR gene family contains variations in gene number and allelic polymorphism. The KIR2DL1, KIR- 2DL2, KIR2DL3 and KIR3DS1 genes had been reported to be benefic in the transplant. The KIR genotyping could be useful for selecting donor and for predicting NK activity.

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