2005, Number 73
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ABSTRACTObjective: To know the normal immunoglobulin (M, G and A) and complement’s component (C3 and C4) concentration at the healthy newborn.
Patients and Methods: Cord blood samples was obtained from newborn’s placentas captured at the Instituto Nacional de Perinatología. By clinical and hematological monitoring, during the first 72 h of intrauterine life, all the newborns were qualified healthy eutrofic. Newborns with age under 28 week of gestation (SDG) or delivery’s products that developed membrane rupture premature over 12 h, or products with infection or congenital malformation were excluded.
Results: One hundred ten newborns were evaluated, 59 males and 51 females. Sixty of them (54.5%) were preterm products and 50 (45.4%) were term products. The IgG average concentration at term newborns (RNT) was 1260 mg7dl, while at preterm newborns (RNPT) was 947 mg/dl. The IgA average concentration at RNT was 8.8 mg7dl, while at RNPT was 1.6 mg/dl. The IgM average concentration at RNT was 18.1 mg7dl, and at RNPT was 13 mg/dl. The C3 average concentration at RNT was 33 mg/dl, while at RNPT 36 mg/dl. The C4 average concentration at RNT was 10.2 mg7dl, while at RNPT 11 mg/dl.
Conclusions: The data suggest that; A) the concentration of certain immunoglobulins and certain complement’s components dose were not different between RNT and RNPT. B) The IgM, IgG e IgA, and C3 y C4´s concentration is higher than the concentration previously reported. And C) It’s probable that the humoral response’s potential at RNT and RNPT could be quite similar.
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