Medicina Cutánea Ibero-Latino-Americana

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>Journals >Medicina Cutánea Ibero-Latino-Americana >Year 2010, Issue 4

Lezcano L, Di Martino B, Galeano G, Aldama A, Rodríguez M, Knopfelmacher O, Bolla L
Vasculonecrotic reactions in leprosy. Two cases of Lucio’s phenomenon
Med Cutan Iber Lat Am 2010; 38 (4)

Language: Español
References: 10
Page: 161-163
PDF: 144.73 Kb.

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The Lucio’s phenomenon (LP), probably mediated by immune complexes, is a severe necrotizing skin reaction that occurs mainly in patients with nonnodular lepromatous leprosy. The literature review shows that there is an inadequate use of this definition. Several authors identify as LP the vasculonecrotic reactions that occur in other forms than the diffuse leprosy. We present two cases of patients with Hansen’s disease, who developed vasculonecrotic reactions.

Key words: Lucio’s phenomenon, Hansen’s disease, vasculonecrotic reactions.


  1. Helmer KA, Fleischfresser I, Kucharski L, Fillus Neto J, Rodríguez Santamaría J. Fenómeno de Lucio (eritema necrosante) na gestacao. An bras Dermatol 2004; 79: 205-10.

  2. Fogagnolo L, Macedo de Souza E, Cintra ML, Neves Ferreira Velho E. Vasculonecrotic reactions in Leprosy. Brazilian Journal of Infectous Diseases 2007; 11: 378-82.

  3. Pursley TV, Jacobson RR, Apisarnthanarax P. Lucio’s Phenomenon. Arch Dermatol 1980; 116: 201-4.

  4. Moschella SL. The lepra reaction with necrotizing skin lesions: a report of six cases. Arch Dermatol 1967; 95: 565-75.

  5. Sehgal VN. Lucio’s phenomenon/erythema necroticans. In J Dermatol 2005; 44: 60-5.

  6. Ang P, Tay YK, Ng SK, Seow CS. Fatal Lucio phenomenon in 2 patients with previously undiagnosed leprosy. J Am Acad Dermatol 2003; 48: 958-61.

  7. Euzebio SL, Leite E, Alves HL, Sales de Souza L. Vasculitis in Leprosy Mimicking Rheumatic diseases. Rev Bras Reumatol 2007; 47: 140-4.

  8. Hussain R, Lucas SB, Kifayet A et al. Clinical and histological discrepancies in diagnosis of ENL reactions classified by assessment of acute phase proteins SAA and CRP. Int J Lepr 1995; 63: 222.

  9. Aldama AB, Correa J, Rivelli V, Mendoza G. Fenômeno de Lucio. Comunicación de 4 casos em lepra no difusa. Méd Cutan Iber Lat Am 2002; 30: 229-33.

  10. Innami S, Leguizamón OR, Alvarenga AE. 2 cases of Lucio phenomenon in Paraguay. Repura 1973; 42: 12-5.

>Journals >Medicina Cutánea Ibero-Latino-Americana >Year 2010, Issue 4

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