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Órgano Oficial del Instituto Nacional de Pediatría

2010, Number 4

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Acta Pediatr Mex 2010; 31 (4)

Influenza A H1N1 (swine flu) in children seen at the Instituto Nacional de Enfermedades Respiratorias

Garrido C, Cano C, Salcedo M, Razo R, Alejandre A

Language: Spanish
References: 11
Page: 162-167
PDF size: 490.15 Kb.


ABSTRACT

In March, 2009, the report of patients with influenza by a virus with a genetic combination that had never been identified, was seen to be on the increase in Mexico. H1N1 Influenza A virus of swine origin, was a new epidemic.
Three months after the epidemiologic alert declared by the Mexican government, the World Health Organization (WHO) reported 6,225 confirmed cases in 73 countries. This event prompted the WHO to declare a pandemia on June 11th.
We did a retrospective study of the clinical files of 36 children with a confirmed result of H1N1 influenza A from March to November 2009 at the Instituto Nacional de Enfermedades Respiratorias (INER).
The age of the patients ranged from 9 months to 14 years.16.7% of them had history of exposure to H1N1 influenza A; 33% had been vaccined against seasonal influenza for 2008 to 2009. Patients presented with cough (100%), fever (83%), respiratory distress (83%), rhinorrhea (69.5%). Relevant laboratory findings were: leukopenia (44%), lymphocytopenia (88%), monocytosis (55), elevated lactic dehydrogenase (91%); and creatininephosphokinase (56%). Three patients died.


REFERENCES

  1. Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team* NEJM 2009;360:2605-15.

  2. Smith TF, Burgert EO Jr, Dowdle WI, Noble GR, Campbell RJ, Van Scoy RE. Isolation of swine influenza virus from autopsy lung tissue of man. N Engl J Med 1976;294:708-10.

  3. Ito T, Cauceiro JN, Keim S, Baum LG, Krauss S, Cashucci MR, Donatelli I, Kida H, Paulson JC, Webster RG, Kawaoka Y. Molecular basis for the generation in pigs of influenza A viruses with pandemic potencial. J Virol 1998;72:767-73.

  4. Secretaria de Salud México. Estadisticas. Available at URL http://portal.salud.gob.mx/contenidos/noticias/influenza/estadisticas. Accessed 10th december 2009.

  5. Perez-Padilla R, De la Rosa-Sanboni M, Parra-de León S, Hernández M, Quiñones-Falconi F, Bautista E, Ramírez-Venegas A, Rojas-Serrano J, Ormsbyc CE, Higuera A, Mondragón E, Córdova-Villalobos JA. INER Working Group Influenza. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009;361:680-9.

  6. Hackett S, Hill L, Patel J, Ratnaraja N, Ifeyinwa A, Farooqi M, Nusgen U, Debenhan P, Gandhi B, Makwana N, Smit E, Welch S. Clinical characteristics of paediatric H1N1 admissions in Birmingham, UK. Lancet 2009;374:605.

  7. Lister P, Reynolds F, Parslow R, Chan A, Cooper M, Plunkett A, Riphagen S. Swine-origin influenza virus H1N1, seasonal influenza virus, and critical illness in children. Lancet 2009;374:605-6.

  8. Surveillance for pediatric deaths associated with 2009 pandemic influenza A (H1N1) virus infection- United States, April-August 2009. MMWR Morb Mortal Wkly Rep 2009;58(34):941-7.

  9. Beigel J. Influenza. Crit Care Med 2008;36:2660-6.

  10. Interim Guidance for Infection Control for Care of Patients with Confirmed or Suspected Swine Influenza A (H1N1) Virus Infection in a Healthcare Setting. CDC. October 14, 2009.

  11. Weekly epidemiological record. OMS. No. 21, 22 mayo 2009.




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