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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2009, Number 07

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Ginecol Obstet Mex 2009; 77 (07)

Vaginal adenosis and vaginal intraepithelial neoplasia: a review of the literature and a case report

González GA, Vera GD, López CC
Full text How to cite this article

Language: Spanish
References: 13
Page: 329-334
PDF size: 447.33 Kb.


Key words:

vaginal adenosis, vaginal intraepithelial neoplasia, CO2 laser.

ABSTRACT

Vaginal adenosis is an uncommon pathology, characterized by the presence of cylindrical epithelium in the vagina. This pathology is considered rare if not found in women exposed in utero to diethylstilbestrol (dietilestilbestrol). Vaginal intraepithelial neoplasia (VAIN) is another uncommon condition in women who have not been hysterectomized to treat cervical intraepithelial neoplasia (CIN), with an incidence of 0.3 per 100000 women. On the other hand 0.9% of the patients who have been poshysterectomized to treat CIN develop VAIN. This paper aims at reviewing the literature on vaginal adenosis, vaginal intraepithelial neoplasia and their possible treatments. In addition, the paper reports on a case of vaginal adenosis in a young female patient with concomitant VAIN 2, the CO2 laser ablation performed, and the short-term results obtained.


REFERENCES

  1. Kranl C, Zelger B, Kofler H, Him K, et al. Vulval and vaginal adenosis. BJD 1998;128-31.

  2. Kurman RG, Scully RE. The incidence and histogenesis of vaginal adenosis: an autopsy study. Hum Pathol 1974;(5):265-76.

  3. Herbst AL, Kurman RJ, Scully RE, Poskanzer DC. Clear cell adenocarcinoma of the genital tract in young females: Registry report. N Engl J Med 1972;25:287-1259.

  4. Schockaert S, Poppe W, Arbyn M, Vrguts T, Verguts J. Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: A retrospective study. Am J Obst Gynecol 2008;199(2):113e1-113e5.

  5. González SJ, Flores MG, Deolarte MJ, Rios MT, Hernandez MA. Effectiveness of 5-fluorouracil in the treatment of vaginal intraepithelial neoplasia in mexican population. J Low Gen Tr Dis 1998;2(4):221-28.

  6. Buck HW, Guth KJ. Treatment of vaginal intraepithelial neoplasia (primarily low grade) with imiquimod 5% cream. J Low Gen Tr Dis 2003;7(4):290-3.

  7. Lin H, Huang EY, Chang HY, Chang ChCC. Therapeutic effect of topical applications of trichloroacetic acid for vaginal intraepithelial neoplasia after hysterectomy. Jap J Clin Onc 2005;35(11):651-54.

  8. Massad LS. Diagnosis of vaginal intraepithelial neoplasia. J Low Gen Tr Dis 2008;12(1):16-19.

  9. Sandberg EC, Danielson RW, Cauwet RW, Bonar BE. Adenosis vaginal. Am J Obstet Gynecol 1965;93:209-22.

  10. Herst AL, Kurman RJ, Scully RE. Vaginal and cervical abnormalities after exposure to stilbestrol in utero. Obstet Gynecol 1972;40:287-98.

  11. Herbst AL, Ulfelder H, Poscanzer DC. Association of maternal therapy with tumor appearance in young woman. N Engl J Med 1971;284:878-81.

  12. Noller KL, Fish DR. Diethylstilbestrol Usage: Is interesting past, important present, and questionable future. Med Clin N Am 1974;58:793-96.

  13. Forsberg JG. Estrogen, vaginal cancer and vaginal development. Am J Obstet Gynecol 1972;113:83-87.




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Ginecol Obstet Mex. 2009;77