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2010, Number 1

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Patol Rev Latinoam 2010; 48 (1)

Focal glomerulopathy with foamy cells. An infrequent form of presentation of focal and segmental glomerulosclerosis

Drut R
Full text How to cite this article

Language: Spanish
References: 6
Page: 36-38
PDF size: 139.03 Kb.


Key words:

glomerular foamy cells, focal and segmental glomerulosclerosis, nephrotic syndrome.

ABSTRACT

This paper reports the case of a 27-year-old man with nephrotic syndrome in whom the kidney biopsy showed focal and segmental glomerular foamy cells. The finding was difficult to interpret and was defined two years later when a new kidney biopsy revealed the classical features of focal and segmental glomerulosclerosis (FSG). Although foamy cells may present in FSG the finding consistently associates with clearcut classical glomerular lesions and has not been reported es the presenting feature. The finding might represent the earliest recognizable lesion of this condition in accordance to the proposed pathogenesis for FSG.


REFERENCES

  1. Renwick N, Nasr SH, Cheng W, et al. Foamy podocytes. Am J Kidney Dis 2003;41:891-896.

  2. Stokes MB, Valeri AM, Markowitz GS, et al. Cellular focal segmental glomerulosclerosis: Clinical and pathologic features. Kidney Int 2006;70:1783-1792.

  3. Reidy K, Kaskel FJ. Pathophysiology of focal segmental glomerulosclerosis. Pediatr Nephrol 2007;22:350-354.

  4. Hogg R, Middleton J, Vehaskari VM. Focal segmental glomerulosclerosis, epidemiology aspects in children and adults. Pediatr Nephrol 2007;22:183-186.

  5. Of focal segmental glomerulosclerosis: a working proposal. Am J Kidney Dis 2004; 43:368-382.

  6. D'Agati VD. Podocyte injury in focal segmental glomeruloscle Int 2008;73:399-406.




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C?MO CITAR (Vancouver)

Patol Rev Latinoam. 2010;48