Mecanismo fisiopatológico de la disfunción tiroidea inducida por el uso de amiodarona

Natalia Lo Zhang

2010, Number 594

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Rev Med Cos Cen 2010; 67 (594)

Mecanismo fisiopatológico de la disfunción tiroidea inducida por el uso de amiodarona

Lo ZN

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Language: Spanish
References: 10
Page: 369-371
PDF size: 259.13 Kb.

ABSTRACT

Amiodarone is a highly effective agent for the prophylaxis and treatment of many cardiac rhythm disturbances, like paroxysmal atrial fibrillation until life threatening ventricular tachyarrhythmia. They are related with several pathogenetic mechanisms like disturbance of thyroid iodine autoregulation, thyroid cytotoxicity, autoimmunity effects on the thyroid and interactions of amiodarone with the thyroid hormone receptor. It may cause an increase in serum levels of thyroxine, reverse triiodothyronine, and thyroid-stimulating hormone and a decrease in serum triiodothyronine levels.

REFERENCES

Angelo A, Harjai MD, Kishore J, Licata MD. Effect of Amiodarone on Thyrid Function. Ann Intern Med 1997;126:63-73
Bartelena L, Bogazzi F, Braverman L, Martino E. The effects of Amiodarone on the Thyroid. Endocrine Reviews 22 (2): 240-254, 2001
Bednarek-Tupikowska G, Bugajski J. Filus A, Kuliczkowska J. Amiodarone and the thyroid gland. Postepy Hig Med Dosw. 2004 Apr 20;58:216-25.
Burgess JR, Claxton S, Donovan S, Greenaway TM, Hoffman L, Loughhead M, Sinha SN. Amiodarone-associated thyrotoxicosis: an indication for thyroidectomy. Aust N Z J Surg. 2000 Mar;70(3):174-8.
Davies DW, Newman CM, Price A Weetman AP. Amiodarone and the thyroid: a practical guide to the management of thyroid dysfunction induced by amiodarone therapy. Heart 1998; 79; 121-127.
De Luis Roman D, Hervilla Ezquerra S, Lahera Vargas M, Maldonado Castro G, Zurita Sepulveda P. Amiodarone and the thyroid.Rev Clin Esp. 1999 Apr; 199(4):227-32.
Gentiloni Silveri N, Mazzone M, Testa A, Ursella S. Amiodarone-induced thyroid dysfunction in clinical practice. Eur Rev Med Pharmacol Sci. 2006 Sep-Oct;10(5):269-78
Maji D. Hyperthyroidism. J Indian Med Assoc. 2006 Oct;104(10):563-4, 566-7.
Saikia UK, Saikia M. Drug-induced thyroid disorders. J Indian Med Assoc. 2006 Oct;104(10):583, 585-7, 600.
Sandhu RS, Davies PH. Amiodarone induced thyroid dysfunction: pathophysiology, diagnosis and management. Adverse Drug React Toxicol Rev. 2001 Jun; 20(2):105-16.