Floriano-Sánchez E, Torres-Salazar JJ, Cárdenas-Rodríguez N, Castro-Marín M, Zapata- Villalba MA, Flores-Terrazas JE

Language: Spanish
References: 8
Page: 273-277
PDF size: 811.82 Kb.

ABSTRACT

Background: Recent reports have placed prostate cancer in third place worldwide. In Mexico it is the principal cause of death by cancer after skin cancer. Oxidative stress has been observed to play a role in cancer etiology. The present study evaluates whether or not there is any alteration in endothelial nitric oxide synthase, an oxidative stress marker, in prostate cancer and benign prostatic hyperplasia.
Methods: Thirty-nine benign prostatic hyperplasia tissue samples and forty-two prostate cancer tissue samples were obtained and conditions were standardized in order to immunohistochemically detect the presence of endothelial nitric oxide synthase in the tissues.
Results: The percentage of area immunoreactive for endothelial nitric oxide synthase was 1.1779±0.25% in prostate cancer tissue and 3.162±0.32% in benign prostatic hyperplasia tissue.
Conclusions: Densitometric data for endothelial nitric oxide synthase immunoreactivity in prostate cancer glandular tissue were lower than those obtained in similar benign prostatic hyperplasia tissue. In accordance with the above, endothelial nitric oxide synthase determination could be used as a differentiation marker in early stages of prostate cancer.

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