2009, Number 3
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ABSTRACTIntroduction: Primary cancer of tethra is rare and represents about 0.02% of all neoplasia found in women and the majority of them are squamous cell carcinomas. Diagnosis is difficult due to the fact that the disease has usually reached advanced stage. Prognosis is dependent on clinical stage at the moment of diagnosis and tends to be poor.
Clinical case: This case is a 56-year-old female patient diagnosed with poorly defined primary papillary transitional cell carcinoma of the urethra with positive lymph nodes.
Discussion: Primary carcinoma of the urethra is a rare tumor with a higher incidence in women than in men (4:1). It most commonly appears in the sixth decade of the patient’s life. Chronic inflammatory processes and human papillomaviruses 16 and 18 have been associated as possible etiological factors. By 2004 one thousand two hundred cases had been described in women and 600 cases in men. Disease stage is the most important survival prognosis factor. Treatment is determined by the sex of the patient, disease stage, histological type, extension and localization.
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