2009, Number 6
Rev Mex Urol 2009; 69 (6)
Mn-superoxide dismutase (Mn-SOD) expression levels and prostate specific antigen correlation in prostate cancer
Floriano-Sánchez E, Cárdenas-Rodríguez N, Castro-Marín M, Flores-Terraza J, Torres-Salazar JJ
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ABSTRACTIn addition to its antioxidant function, manganese superoxide dismutase (Mn-SOD) plays a role in tumor suppression in different neoplasms, including prostate tumors. Greater Mn-SOD expression in prostate cancer (CaP) tissue than in benign prostate hyperplasia (BPH) tissue in stromal cells as well as glandular tissue has been demonstrated. Prostate specific antigen (PSA), even levels below 4.0 ng/mL, is known to be a CaP risk marker and only 8% of the cancer-free population presents with higher PSA levels. The present study analyzes Mn-SOD expression levels in CaP tissue and correlates them with PSA levels.
Materials and methods: PSA level was retrieved from case records and Mn-SOD expression levels were determined by immunohistochemistry.
Results: Of the 26 diagnosed cancer tissue samples, no correlation was found between Mn-SOD expression levels and PSA levels. Data was analyzed using Pearson correlation with an index of 0.04182 and p-value was P=0.4163.
Conclusions: There was no correlation between Mn-SOD expression levels and PSA levels in the cancer tissue studied.