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Archivos de Medicina de Urgencia de México

2011, Number 1

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Arch Med Urg Mex 2011; 3 (1)

Intravenous levetiracetam in treatment of epilepsy in the Emergency Department

Santos ZJ, Benítez DAI, Castro ME

Language: Spanish
References: 5
Page: 34-40
PDF size: 260.93 Kb.


ABSTRACT

Levetiracetam is an antiepileptic drug with a pharmacokinetic profile (no protein binding, significant renal elimination, no enzyme induction) which facilitates its use in a wide range of complex clinical situations. The recent availability of an intravenous formulation gives the doctor emergency physician and neurologist a new option for fast and safe treatment in the Emergency Room, where the common use of other agents such as phenytoin, may be clinically difficult. With a limited range of available antiepileptic drugs for use in the Emergency Department, levetiracetam is a drug that is administered parenterally very useful, especially in patients where drug interactions may be important, if not the main concern. The aim of this paper is to review the most relevant information of this new antiepileptic drug and its formulation for intravenous infusion and analyze their usefulness in the Emergency Department.


REFERENCES

  1. Información para prescribir levetiracetam. SSA. 20 enero 2010.

  2. Ramael S, Daoust A, Otoul C, Toublanc N, Troenaru M, Lu Z, Stocki A. Levetiracetam intravenous infusion: A randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia 2006; 47 (7): 1128-1135.

  3. Ramael S, De Smedt F, Toublanc N, Otoul C, Boulanger P, Riethuisenand JM, Stockis A. Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clin Ther 2006; 28: 734-744.

  4. Baulac M, Brodie MJ, Elger CE, Krakow K, Stockis A, Meyvisch P, Falte U. Levetiracetam intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures. Epilepsia 2007; 48 (3): 589-592.

  5. Burakgazi E, Hynicka L, Towne A, Pellock JM. The use of intravenous levetiracetam in epilepsy patients and its efficacy, AES proceedings. Epilepsia 2008; 49 (suppl. 7): 426 1-498, 2008.




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