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>Journals >Dermatología Revista Mexicana >Year 2011, Issue 1

Cruz PDMC, Padilla DMC, Alonzo-Romero PL, Palma RA, Peralta PML
Candidine treatment in patients with recalcitrant warts
Dermatología Rev Mex 2011; 55 (1)

Language: Español
References: 29
Page: 9-16
PDF: 497.94 Kb.

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Background: Viral warts are a common disease in humans. They are considered recalcitrant when do not respond to any therapeutic regimen or relapse quickly. There is no choice treatment but different therapeutic modalities with variable effect. The destructive methods are most used, but in case reports candidin seems to be promising and is proposed as a therapeutic mechanism with immunostimulant effect.
Objective: To determine the efficacy and safety of treatment with intralesional candidin for 12 weeks, compared with saline solution.
Patients and method: In a randomized, double-blind, placebo-controlled sudy patients older than six years (from the outpatient consult of Centro Dermatologico Pascua from November 1, 2008 to March 1, 2009) with a clinical diagnosis of common warts that had not responded to at least two treatments. We excluded patients with diabetes, hypertension, pregnancy, lactation, immunosuppressant, genital warts, generalized dermatitis or a history of allergy to antigenic preparations. The study group was treated with a yeast-derived antigen from Candida albicans (candidin) and the placebo group with 0.9% saline solution, both intralesional, in the oldest or larger wart with a dose of 0.1 cc in three applications, with an interval of four weeks among each.
Results: There were no significant differences between groups with respect to age, duration, size of the lesion, total number of injuries and number of prior treatments. In the study group, the number of healing was 43%, and in the control group 15% (χ2, p = 0.04). The relative risk reduction was 1.9, and the number needed to treat was 3.6 (95%). Mild adverse events were observed.
Conclusions: Candidin intralesional immunotherapy is an effective and safe treatment in patients with recalcitrant warts.

Key words: recalcitrant warts, candidin, clinical trial, immunostimulation, placebo effect.


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>Journals >Dermatología Revista Mexicana >Year 2011, Issue 1

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