Dermatología Revista Mexicana

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Dermatología Revista Mexicana >Year 2011, Issue 1

Soto OJA, Amezcua RG, Guardado LI, Bologna MR
Acantosis nigricans: oral manifestations
Dermatología Rev Mex 2011; 55 (1)

Language: Español
References: 11
Page: 47-50
PDF: 373.55 Kb.

Full text


The acantosis nigricans is a syndrome that affects both the skin and the mucosas; it is characterized by papilomatosus injuries in mucosas of the mouth and pigmented alterations of the skin. It can be with or without association to malignant neoplasm, generally gastric adenocarcinoma. The mouth manifestations of this disease are more common when it is associated to malignant neoplasm and they are characterized by papillomatosus proliferations in lips, gums and tongue. The treatment is symptomatic and skin and mouth injuries may relieve having treated the neoplasm. This paper describes a clinical case, emphasizing the mouth manifestations important to the dentist and dermatology, as well as the multidisciplinary management of these patiently.

Key words: acanthosis nigricans, oral multiple papillomatosis.


  1. Brown J, Winkelmann RK. Acanthosis nigricans: a study of 90 cases. Medicine (Baltimore) 1968;47:33-51.

  2. Curth HO. The necessity of distinguishing four types of acanthosis Proceedings of XIII International Congress of Dermatology, Munich. Berlin: Springer-Verlag, 1968;p:557-558.

  3. Moller DE, Flier JS. Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med 1991;325:938-948.

  4. Ellis DL, Kafka SP, Chow JC, Nanney LB, et al. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat, and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Engl J Med 1987;317:1582-1587.

  5. Burke JP, Duggirala R, Hale DE, Blangero J, Stern MP. Genetic basis of acanthosis nigricans in Mexican Americans and its association with phenotypes related to type 2 diabetes. Hum Genet 2000;106(5):467-472.

  6. Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol 1994;31:1-19.

  7. Sedano HO, Gorlin RJ. Acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1987;63:462-467.

  8. Kozlowski LM, Nigra TP. Esophageal acanthosis nigricans in association with adenocarcinoma from an unknown primary site. J Am Acad Dermatol 1992;26:348-351.

  9. Yeh JS, Munn SE, Plunkett TA, Harper PG, et al. Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. J Am Acad Dermatol 2000;42(2 Pt 2):357-362.

  10. Ramirez Amador V, Esquivel Pedraza L, Caballero Mendoza E, Berumen Campos J y col. Oral manifestations as a hallmark of malignant acanthosis nigricans. J Oral Pathol Med 1999;28:278-281.

  11. Mostofi RS, Hayden NP, Soltani K. Oral malignant acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1983;56(4):372-374.

>Journals >Dermatología Revista Mexicana >Year 2011, Issue 1

· Journal Index 
· Links 

Copyright 2019