Flores-Nava G, Pérez-Aguilera TV, Pérez-Bernabé MM

Language: Spanish
References: 8
Page: 101-106
PDF size: 243.29 Kb.

ABSTRACT

Introduction: The incidence of congenital malformations ranges from 3 to 5% in neonates and increases to 7.8% when babies are exposed to teratogens, infections or when they suffer a chronic or degenerative disease.
Objective: To assess the frequency and type of congenital malformations detected in neonates during a 4 year period in a General Hospital. Methods: A descriptive study reviewing the records of live or dead neonates born with a congenital malformation. We analyzed, the prevalence, the age of the mother and father, the number of pregnancies, gestational age, gender, and birth weight and type of delivery. Descriptive statistic was used.
Results: In 22,327 live or dead births, 416 (18.6 per 1000) neonates had one malformation; because some had two or more defects, the total number of malformations was 664 (29.7 per 1000). The most common malformations were cleft lip and palate in 52 cases, followed by ear appendices in 33, and Down syndrome in 31. The systems most frequently affected were muscle-skeletal in 277, skin in 80 and central nervous system in 77.
Conclusions: The prevalence in this study of 29.7 per 1,000 births is higher than that reported in other series.

REFERENCES

1. Opitz JM. Association and syndromes: terminology in clinical genetics and birth defects epidemiology: comments on Khoury, Moore and Evans. Am J Med Genet 1994;49:14-20.

2. Jurado GE, Mutchinick O, Urrusti SJ, Vargas GC. A public health problem in México. Gac Med Mex 2006;132:141-82.

3. Ray JG, O’Brien TE, Chan WS. Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis. QJ Med 2001;94:435-44.

4. Tena TC, Ahued JR, García CR, Aneull LG, y col. Recomendaciones específicas para mejorar la atención médica en el diagnóstico prenatal. Ginecol Obstet Mex 2004;72:415-42.

5. Gallegos RMC, Romero GG, Pérez LNM, Salazar TM. Defectos congénitos mayores y múltiples en neonatos de mujeres atendidas en un hospital de tercer nivel. Ginecol Obstet Mex 2007;75:47-52.

6. Alfaro AN, Pérez MJJ, Valadez FI, González TYS. Malformaciones congénitas externas en la zona metropolitana de Guadalajara.10 años de estudio. Investigación en Salud 2004;6:180-7.

7. Valdés MJM, Blanco AME, Kofman S, Mutchinick O. Defectos congénitos en el Hospital General de México. Frecuencia observada durante 10 años mediante el RYVEMCE. Rev Med Hosp Gral Mex 1997;60:181-7.

8. Hernández RG, Alvarenga CR. Frecuencia de malformaciones externas en recién nacidos de la Unidad Materno Infantil del Hospital Escuela. Factores de riesgo. Rev Med Post UNAH 2001;6:148-53.