2011, Number 1
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ABSTRACTMalignant cutaneous adnexal neoplasms are rare; however, it is important to know them because some are rapidly progressive and fatal, and their diagnosis is one of the most challenging tasks for the general pathologist due to its great similarity with its benign counterpart and also because the differential diagnosis between themselves and some metastatic tumors (salivary gland and breast) may be problematic. There is no clinical findings that help us to their diagnosis, although they generally are grater than 2.5 cm. Histopathologically, the irregular and asymmetric shape is the most relevant finding; the neoplastic cells may exhibit mild to atypical changes, accentuated polymorphism; generally atypical mitosis are rare (one per field of 40 X); necrosis, lymphatic, vascular and neural invasions are frequent. The IHQ is useful only in some cases. Treatment of choice is wide surgical resection with elective lymph node dissection.
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Mentzel T, Requena L, Kaddu S, Soares de Aleida LM, et al. Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol 2003;30:294-302.