Donohue-Cornejo A, Guzmán-Gastelum DA, Constandse-Cortéz D, Gaitán-Cepeda LA, Reyes-Escalera C

Language: Spanish
References: 12
Page: 189-192
PDF size: 339.44 Kb.

ABSTRACT

The Plummer-Vinson syndrome, called sideropenic dysphagia, is characterized by dysphagia, iron deficiency, anemia and the presence of esophageal webs, and it has been identified as a risk factor for developing squamous cell carcinoma of the upper gastrointestinal tract. The cases of patients suffering Plummer-Vinson syndrome that develops intraoral carcinomas are very rare. We present one case of 45 years-female with diagnosis of sideropenic dysphagia who develops a squamous cell carcinoma of the tongue. The patient present at Oral Medicine and Oral pathology clinic at Dental School of the Autonomous University of Ciudad Juárez, México by glossodynia, glossopyrosis and dysphagia of 8 months of evolution. The medical file revealed antecedents of non-specified chronic anemia, with blood transfusions at medical institutions. The intraoral examination showed depapilation of two anterior thirds of the tongue. An ulcerated swallow with indurate borders site in the left lateral border of the tongue of unknown evolution was observes. An incisional biopsy was done and a histopathological diagnosis of squamous cell carcinoma of the tongue was emitted. In our knowledge this is the third case reported in the scientific literature of a lingual squamous cell carcinoma develops in a patient suffering Plummer-Vinson syndrome. The 3 reported cases are coincident in age, gender and oral features. The pertinence of to continue including to sideropenic dysphagia like a risk factor to develop intra-oral carcinomas is discuses.

REFERENCES

1. Novacek G. Plummer-Vinson syndrome. Orphanet J Rare Diseases 2006; 1: 36. doi. 10.1186/1750-1172-1-36.

2. Jessner W, Vogelsang H, Püspök A, Ferenci P, Gangl A, Novacek G, Bodisch A, Wenzl E. Plummer-Vinson syndrome associate with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue. Am J Gastroenterol 2003; 98 (5): 1208-9.

3. Larsson LG, Sandström A, Westling P. Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in sweden. Cancer Res 1975; 35(11 pt2): 3308-16.

4. Kim KH, Kim MC, Jung GJ. Gastric cancer occurring in a patient with Plummer-Vinson syndrome. World J Gastroenterol 2005; 11 (44): 7048-50.

5. Khan FY, EL-Hiday AH, Morad NA. Plummer-Vinson syndrome associated with solid pseudopapillary tumor of the pancreas. Chin Med J 2007; 120 (17): 1553-5.

6. Rincón SRA, Hani AA, Alvarado BJ. Síndrome de Plummer-Vinson. Rev Col Gastroenterol [online]. 2004; 19 (4): 288-29.

7. La Grassa M, Tamburo De Bella A, Beltrame A. The Plummer-Vinson syndrome within the general pictures of precancerous condition of the tongue. Riv Ital Stomatol 1967; 22 (12): 1458-71.

8. Santoro E, Gambardella P, Piscicelli I. On the Plummer-Vinson syndrome with precancerous lesion of tongue. Rass Int Clin Ter 1970; 50 (12): 753-61.

9. Just-Sarobé M. Smoking and skin. Actas Dermosifilogr 2008; 99 (3): 173-84.

10. de Moura CMJR, Alves HH, de Souza L, Livingstone D, Hardy MD, Costa TR, Mamede RCM. Prognostic factors in squamous cell carcinoma of the oral cavity. Rev Bras Otorrinolaringol 2008; 74: 861-6.

11. Wang YH, Chen YF, Guo ZM, Zhang Q, Liu TR, Chen FJ. Reason for recurrence and prognostic analysis of early stage squamous cell carcinoma of the oral tongue. Chin J Can 2009; 28 (5): http://www.cjcsysu.cn/cn/article.asp?id=15334

12. Wahlberg PC, Andersson KE, Biörklund AT, Möller TR. Carcinoma of the hypopharynx: analysis of incidence and survival in Sweden over a 30-year period. Head Neck 1998; 20 (8): 714-9.