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Revista de Endocrinología y Nutrición

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2010, Number 4

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Rev Endocrinol Nutr 2010; 18 (4)

Muscular weakness in a patient with systemic hypertension

Ferreira-Hermosillo A, Bernal-Garduño J, Hernández-García I, Molina-Ayala M
Full text How to cite this article

Language: Spanish
References: 5
Page: 194-196
PDF size: 239.64 Kb.


Key words:

Muscular weakness, hypokalemia, hyperaldosteronism.

ABSTRACT

The medical approach of a patient with muscular weakness should include a search for endocrine conditions. We present the case of a young man with hypokalemia, hypertension and metabolic alkalosis with suspicion of primary hyperaldosteronism. The diagnostic process includes determination of aldosterone to renin ratio as a screening test under normokalemic conditions and with an adequate blood pressure control. Diagnosis confirmation includes oral sodium loading test, saline infusion test and fludrocortisone suppression test. Finally, computed tomography is the most widely used imaging test. The main objective of management is to prevent the morbidity and mortality associated with hypertension and hypokalemia.


REFERENCES

  1. Márquez-Valero OA, Rojas-Velasco G, Ramos-Rivas M, Cruz-Cruz EA, Bierzwinsky-Sneider G, Zacarías-Castillo R. Parálisis periódica hipocalémica relacionada con tirotoxicosis. Med Int Mex 2007; 23: 120-125.

  2. Young W. Minireview: Primary Hyperaldosteronism-Changing concepts in diagnosis and treatment. Endocrinology 2003; 144: 2208-2213.

  3. Fardella CE, Mosso L, Gómez-Sánchez C, Cortés P, Soto J, Gómez L et al. Primary hyperaldosteronism in essential hypertensives: Prevalence, biochemical profile, and molecular biology. J Clin Endocrinol Metab 2000; 85: 1863-1867.

  4. Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008, 93: 3266-3281.

  5. Amar L, Plouin PF, Steichen O. Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism. Orphanet J Rare Dis 2010; 5: 9.




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Rev Endocrinol Nutr. 2010;18