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2011, Number 2

Gac Med Mex 2011; 147 (2)

Prevention of mitochondrial diseases: a hope through assisted reproductive technologies

Piña-Aguilar RE
Full text How to cite this article

Language: Spanish
References: 6
Page: 172-175
PDF size: 75.83 Kb.


Key words:

Mitochondrial disease, mtDNA, Nuclear transfer, Chromosome transfer, Pronuclear transfer.

ABSTRACT

Mitochondrial diseases are a heterogenic and poorly studied group of diseases, considered serious in most cases and currently without treatment. Although assisted reproduction proposed strategies to prevent them, such as pre-implantation genetic diagnosis, these techniques are not sufficiently successful. However, the recent publication of two assistedreproduction techniques–meiotic spindle transfer in nonhuman primates and pronuclear transfer in humans–generate a clear ray of hope for the prevention of these diseases. This review analyzes the characteristics and meaning of these new findings and their future clinical implications.


REFERENCES

  1. Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature. 1988;331:717-9.

  2. Steffann J, Frydman N, Gigarel N, et al. Analysis of mtDNA variant segregation during early human embryonic development: a tool for successful NARP preimplantation diagnosis. J Med Genet. 2006; 43:244-7.

  3. Unsal E, Akta¸s Y, Uner O, et al. Successful application of preimplantation genetic diagnosis for Leigh syndrome. Fertil Steril. 2008;90:2017:e11-3.

  4. Tachibana M, Sparman M, Sritanaudomchai H, et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature. 2009;461:367-72.

  5. Craven L, Tuppen HA, Greggains GD, et al. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature. 2010;465:82-5.

  6. Lee JH, Peters A, Fisher P, Bowles EJ, St John JC, Campbell KH. Generation of mtDNA homoplasmic cloned lambs. Cell Reprogram. 2010;12:347-55.




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Gac Med Mex. 2011;147