Guerrero DÁF, Brambila CA, Téllez JH, Torres BJM, Salazar LSA, Alcocer GP

Language: Spanish
References: 14
Page: 57-64
PDF size: 178.85 Kb.

ABSTRACT

Objective: To evaluate the efficacy of periodontal regeneration in combination with biomaterials CFRP bone in treating periodontal intrabony defects. Introduction: Periodontal disease results in the destruction of tissues supporting the teeth. The ultimate goal of periodontal therapy is to stop the disease progression and regenerate lost tissue, forming a new cementum, new bone and new periodontal ligament, i.e., periodontal regeneration. In the field of tissue regeneration are 3 requirements to get the best result: a scaffold, and cell regulators. In response to these points allow the use of bone biomaterials and bioactive agents such as CFRP. The CFRP consists of a small volume of very specific preparation of a platelet-rich plasma and whose activation allows a biocompatible three-dimensional matrix of fibrin from which release gradually a set of proteins and growth factors that help speed both healing and bone regeneration. An important point to consider in growth factor therapy is the means and the time of the release of these. The bone biomaterial can fill this role during the regeneration process while specific roles depending on the same. Methodology: We present an experimental study, analytical, longitudinal, prospective and open. Which was held at the Graduate Periodontics, Faculty of Dentistry of the Autonomous University of Tamaulipas, selecting 16 intrabony defects, where open curettage were performed with placement of biomaterial according to the group assigned, each with four defects: Group A, placement of CFRP, Group B, graft, allograft and CFRP, Group C and Group D alloplastic, alloplastic and CFRP. Previous periapical radiographic study. protocol was performed to obtain the plasma fraction is. Postoperative radiographic assessments were performed immediately, at 7, 15 and 60 days. And the biopsy at 60 days and 12 months for histology. Results: In relation to the clinical, radiographic and histological findings indicate a postoperative stimulation in all groups of bone regeneration, presenting ideal conditions for periodontal regeneration. Discussion: Bone biomaterials are considered items that have various functions such as: scaffolding, endogenous and exogenous matrix for cell adhesion, through transport of bioactive agents, maintaining the anatomical characteristics of bone defects, preventing the invagination of the adjacent tissues as a physical barrier and maintaining the space required for cellular repopulation. Conclusion: The combination of technical and biomaterials bone regenerative CFRP offer an alternative to obtain suitable quality fabrics. The postoperative clinical, radiographic and histologic was satisfactory in all groups and this latest evidence that this combination is an alternative surgical treatment that aims to achieve both bone and periodontal regeneration.

REFERENCES

1. Aichelmann-Reidy M, Heath C, Reynolds M. Clinical evaluation of calcium sulfate in combination with demineralized freeze-dried bone allograft for the treatment of human intraosseous defects. J Periodontol 2004; 75: 340-347.

2. Nevins M, Giannobile W, McGuire M, Kao R. Platelet-derived growth factor stimulates bone fill and rate of a attachment level gain: results of a large multicenter randomized controlled trial. J Periodontology 2005; 76: 2205-2215.

3. Polimeni G. Biology and principles of periodontal wound healing/regeneration. Periodontology 2000; 2006 (41): 30-47.

4. Okuda K, Kawase T, Momose W. Platelet rich plasma contains high levels of platelet-derived growth factor and transforming growth factor b and modulates the proliferation of periodontally related cells in vitro. J Periodontolog 2003; 74: 849-857.

5. Gregory-George Z, Hoffman O, Kasaj A. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hidroxiapatite/b-tricalcium phosphate bone substitute or bovine-derived xenograft. J Periodontol 2007; 78: 2216-2225.

6. Fleckenstein K, Cuenin M, Peacock M. Effect of a hidroxiapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium. J Periodontol 2006; 77: 39-45.

7. Jensen S, Topoll H, Rengers H, Heinz B, Teich B, Hoffmann T, Al-Machot E, Meyle J and Jervoe-Storm P. Clinical outcomes after treatment of intra-bony defects with an EMD/synthetic bone graft or EMD alone: a multicentre randomized controlled clinical trial. J. Clin Periodontol 2008; 35: 420-438.

8. Mannai C. Early implant loading in severely resorbed maxilla using xenograft, autograft and platelet-rich plasma in 97 patients. J Oral Maxillofac Surg 2006; 64: 1420-1426.

9. Piemontese M, Aspriello S. Treatment of periodontal intrabony defects with demineralized freeze-dried bone allograft in combination with platelet-rich plasma: A comparative clinical trial. J Periodontoloy 2008; 79: 802-810.

10. Anitua E, Andia I. BTI implant system: el primer sistema de implantes con superficie bioactiva. Maxillaris 2001; 39: 2-7.

11. Lynch S, Marx R, Nevins M. Tissue engineering: Applications in oral and maxillofacial surgery and periodontics quintessence books.

12. Klongnoi B, Rupprecht S, Zimmermann R. Lack of beneficial effects of platelet-rich plasma on sinus augmentation using a fluorohidroxyapatite or autogenous bone: an explorative study. J Clin Periodontol 2006; 33: 500-509.

13. Celotti F, Colciago A, Negri-Cesi P. Effects of platelet-rich plasma on migration and proliferation of SaOS-2 osteoblasts: role of platelets-derived growth factor and transforming growth factor-b. Wound Rep Reg 2006; 14: 195-202.

14. Nevins M, Camelo M, Nevins M. Periodontal regeneration in humans using recombinant human platelet-derived growth factor- BB (rhPDGF-BB) and Allogenic. Bone J Periodontol 2003; 74: 1282-1292.