2011, Number 4
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ABSTRACTIn some countries melatonin is chronically used to reduce the symptoms of certain neuropsychiatric diseases in children. Adults consume it mainly to treat sleep disorders. Due to its antioxidant properties, it has also been used in the treatment of some types of cancer. This hormone is used in dermal creams and sunscreens, which promise an antiaging effect on cells. Side effects provoked by long-term use of melatonin are not completely clear. In order to know whether the chronic use of this hormone alters reproduction and the events underlying it, fertility for instance, a review of the influence that melatonin has on the reproductive axis of male mammals, including humans, was proposed.
Frungieri MB, Mayerhofer A, Zitta K, Pignataro OP, Calandra RS, Gonzalez-Calvar SI. Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system. Endocrinology. 2005;146:1541-52.