Flores BBA, Rodríguez MCR, Martín RJ, Fomperoza TÁ, Redondo SF

Language: Spanish
References: 11
Page: 85-91
PDF size: 312.68 Kb.

ABSTRACT

Introduction: Choline (Co) is the quantifiable metabolite by means of protonic spectroscopy by magnetic resonance (ERM 1H) and is recognized as a marker of active tumoral tissue, which increment reflects cells proliferation. The increase in Co level has been compared with other morphological factors and prognosis in order to establish its diagnostic value.
Objectives: To demonstrate the diagnostic value of ERM H1 in the mammary lesions classified as Breast Imaging Reporting and Data System (BI-RADS) 6 of the Colegio Americano de Radiología (CAR) (The American School of Radiology) when comparing choline figures with the malignancy histopatological degree.
Material and methods: In 25 patients with infiltrating ductal carcinoma (CDI) choline integral (ppm) was quantified with a standardized method of RMH1; the tumor size (TT) was measured in MR and malignancy histological graduation was carried out with Scarff-Bloom-Richardson scale (SBR) modified by Elston.
Results: In our work, the biggest incidence in IDC occurred in women in the fifth decade of their life. The tumoral size oscillates between 1.0 and 11.1 cm (4.2 cm median). The presence of Co was positive in 100% of the IDC cases. In the SBR classification, 10 tumors were obtained with degree I (40%), 11 with degree II (44%) and 4 tumors with degree 3 (12%).
Conclusions: Carrying out combined explorations with MR imaging and spectroscopy allows to analyze the existence of anatomical and biochemical alterations more completely, improving the MR specificity. However, capacities and methodology in the diagnosis field, are still under development and accepted protocols do not exist.

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