Synthesis of  Bioactive bone cements by using methyl methacrylate  and either methacrylic acid or diethyl amino ethyl methacrylate

R Vargas Coronado; JM Cervantes Uc; JV Cauich Rodríguez; R Vera Graciano; A Martínez Richa

2001, Number 2

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Rev Mex Ing Biomed 2001; 22 (2)

Synthesis of Bioactive bone cements by using methyl methacrylate and either methacrylic acid or diethyl amino ethyl methacrylate

Vargas CR, Cervantes UJM Cauich RJV, Vera GR, Martínez RA

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Language: Spanish
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Page: 54-55
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ABSTRACT

In this work, we report the synthesis of bone cements by using methyl methacrylate (MMA) as a base monomer and either methacrylic acid (MAA) or diethyl amino ethyl methacrylate (DEAEMA) as comonomers. Bioactive bone cements were obtained after hydroxyapatite (HA) addition in various concentrations. Then, a physico-chemical characterization, with emphasis in their mechanical behaviour was conducted. Residual monomer content was found to vary with composition of the matrix and ceramic concentration but never exceeded 4%. Curing times (t_c), maximum temperatures (T_max) and glass transition temperatures (T_g) depended on the presence of either MAA or DEAEMA. Bone cements prepared with MAA comonomer exhibited short curing times, high T_max and T_g. On the other hand, DEAEMA containing bone cements showed long curing times, low T_max and T_g. The addition of hydroxypatite to these bone cements did not affect their maximum temperatures but increased curing times when DEAEMA was used as comonomer or when MMA was used alone. All bone cements studied fullfilled the minimum compressive strength (70 MPa) required for bone cement use. However, the minimum tensile strength (30 MPa) was only fullfilled by cements prepared without filler and those composites containing either MMA or MAA. The minimum bending strength requirement (50 MPa) was not satisfied by any of the formulations studied.