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2011, Number 598

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Rev Med Cos Cen 2011; 68 (598)

Hepatitis C y diabetes

Cabrera OA
Full text How to cite this article

Language: Spanish
References: 17
Page: 371-376
PDF size: 378.54 Kb.


Key words:

Hepatitis, diabetes, autoimmunity, steatosis, insulin resistance.

ABSTRACT

Hepatitis C virus infection may contribute to the development of diabetes mellitus. Insulin resistance associated hepatitis C virus infection play a role in the progression of hepatitis C virus-related liver disease and fibrosis. Several mechanisms are likely to be involved in the pathogenesis of HCV-related insulin resistance. Although several hypotheses have been made, the link between insulin resistance and hepatitis C infection, and the exact sequence of events is unclear.


REFERENCES

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  2. Antonelli A, Ferri C, Fallah P, Pampana A, et al. Hepatitis C virus infection: Evidence for association with type 2 diabetes. Diabetes care 2005, 28 (10): 2548-2550.

  3. Daniel AL, Houlihan JL, Blum JS, Walsh JP. Type B insulin resistance developing during interferon-α therapy. Endocr Pract 2009, 15 (2): 153-157.

  4. Douglas MW, George J. Molecular mechanism of insulin resistance in chronic hepatitis C. World J Gastroenterol 2009, 15 (35): 4356-4364.

  5. Banerjee S, Saito K, Meyer K, et al. Hepatitis C virus protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the dwnstream Akt/Protein kinase signaling pathway for insulin resistance. J Virol 2008, Vol 82 (6): 2606-2612.

  6. Jadoon NA, Shahzad MA, Yaqood R, et al. Seroprevalence of hepatitis C in type 2 diabetes: evidence for a positive association. Virology Journal 2010, 7:304

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  9. Mehta SH, Brancati FL, Sulkoswski MS, Strathdee SA, et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus in the United Sates. Ann Intern Med 2000, 133: 592-599.

  10. Mehta SH, Brancati FL, Strathdee SA, et al. Hepatitis C virus infection and incident type 2 diabetes. Hepatology 2003, 38: 50-56.

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  12. Persico M, Masarone M, La Mura V, et al. Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis: differences and similarities. World J Gastroenterol 2009, 15 (4): 462-466.

  13. Powers AC. Diabetes mellitus. En: HarIRSon. Principios de Medicina Interna, 17 ed, Mc Graw-Hill, Mexico, 2009, pp 2275-2277.

  14. Rouabhia S, Malek R, Bounecer H. Association of hepatitis C virus infection and diabetes. World J Gastroenterol 2009, 15 (40): 5114-15

  15. Sabharwal S, Delgado-Borrego A, Chung RT. Extrahepatic hepatitis C virus after transplantation: diabetes and renal dysfunction. Liver Transpl 2008, 14: S51-S57.

  16. Wang CS, Wang ST, Yao WJ, Chang TT, Chou P. Hepatitis C virus infection and the development of type 2 diabetes in community.based longitudinal study. Am J Epidemiol 2007, 166: 196-203.

  17. White DL, Ratziu V, El-Serad H. Hepatitis C infection and IRSk of diabetes: a systematic review and meta-analysis. J Hepatol 2008, 49 (5): 831-844.




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Rev Med Cos Cen. 2011;68