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2011, Number 6

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Med Cutan Iber Lat Am 2011; 39 (6)

Persistent, simultaneous, metastasic, acral lentiginous melanoma?

Agustí Ma, Messeguer BF, García RR, Ballester SR, Oliver MV, Alegre MV
Full text How to cite this article

Language: Spanish
References: 8
Page: 264-267
PDF size: 548.02 Kb.


Key words:

Acral lentiginous melanoma, melanoma field cells, recurrence, persistence, skin metastasis.

ABSTRACT

Acral lentiginous melanoma (MLA) represents 5% of all malignant melanomas, and has a frequency of loco-regional metastases greater than other subtypes of melanoma. In clinical practice we observed that a significant percentage of cases of MLA that recurrences in apparently healthy areas of skin, even after making excision with adequate safety margins, as in a case that we present. This could be generated by the presence of so-called “melanoma field cells” recently defined by Bastian.


REFERENCES

  1. MacCormack MA, Cohen LM, Rogers GS. Local melanoma recurrence: a clarification of terminology. Dermatol Surg 2004; 30: 1533-8.

  2. Heenan PJ, Ghaznawie M. The pathogenesis of local recurrence of melanoma at the primary excision site. Br J Plast Surg 1999; 52: 209-13.

  3. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005; 353: 2135-47.

  4. Bastian BC, Kashani-Sabet M, Hamm H, Godfrey T, Moore DH. Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res 2000; 60: 1968-73.

  5. North JP, Kageshita T, Pinkel D, LeBoit PE, Bastian BC. Distribution and significance of occult intraepidermal tumor cells surrounding primary mela - noma. J Invest Dermatol 2008; 128: 2024-30.

  6. Thomas JM, Newton-Bishop J, A’Hern R, Coombes G, Timmons M. United Kingdom Melanoma Study Group; British Association of Plastic Surgeons; Scottish Cancer Therapy Network. Excision margins in high-risk malignant melanoma. N Engl J Med 2004; 19; 350: 757-66.

  7. NCCN Practice Guidelines in Oncology v.2.2010 Melanoma.

  8. Haigh PI, DiFronzo LA, McCready DR. Optimal excision margins for primary cutaneous melanoma: a systematic review and metaanalysis. Can J Surg 2003; 46: 419-26.




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C?MO CITAR (Vancouver)

Med Cutan Iber Lat Am. 2011;39