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Colegio de Medicos y Cirujanos República de Costa Rica

2011, Number 599

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Rev Med Cos Cen 2011; 68 (599)

Síndrome Peutz-Jeghers: reporte de un caso y diagnósticos diferenciales con otros síndromes genéticos cutáneos

Torres-Flores J, Morales-Ruvalcaba E, Sotelo-Medina V, Muñoz-Llera E

Language: Spanish
References: 14
Page: 491-494
PDF size: 320.96 Kb.


ABSTRACT

Peutz-Jeghers syndrome (PJS) is a genetic disease caused by mutation of the tumor suppressor gene STK11; is characterized by lenticular hyperpigmented macules on the lips, oral mucosa, distal region of the extremities and gastrointestinal polyps with high risk of malignant neoplasias. Early stages of PJS can mimic other cutaneous syndromes that must be considered. Shows the case of an adolescent male with Peutz-Jeghers syndrome in whom the cutaneous signs were prior to the gastrointestinal features and discusses some differential diagnosis with other dermatological syndromes.


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