2011, Number 4
Presence of maternal anti-dengue IgG antibodies in a group of newborns in Colima, México
Espinoza-Gómez F, Osuna RJF, Newton-Sánchez OA, Delgado EI, De La Cruz RM, Melnikov V
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Language: Spanish
References: 8
Page: 15-19
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ABSTRACT
Dengue epidemics remain as a priority public health problem especially in tropical countries. Mainly the presence of dengue hemorrhagic fever or other severe forms of the disease represent the greatest social and economic burdens to affected populations. These costs are even greater when dealing with younger populations, as occurs in Southeast Asian countries where rates of severe dengue are highest amongst newborns and little infants. One possible explanation for this phenomenon is that a high proportion of mothers sensitized against dengue transfers the immunoglobulin (IgG) antibodies to their products, which provide partial protection against the specific serotype that were exposed, but, on the other hand, this partial immunization induces a mechanism named antibody enhanced captation of the virus, wich provoke the severe forms of dengue in the presence of secondary infection. In order to explore the frequency of transfer of anti-dengue IgG antibodies to newborns in a hyperendemic area such as Manzanillo, Colima, we analyzed the serum of 66 newborns and from 144 mothers, finding a frequency of 24.4% and 18.4% respectively, confirming the transfer of maternal IgG antibodies to child, although in a much smaller proportion than that found in Asia, which could explain why in Mexico, newborns and young children are not the most affected by the severe forms of dengue.REFERENCES