2011, Number 4
Perinatol Reprod Hum 2011; 25 (4)
Comparison of two natural surfactants in the profilactic treatment of respiratory distress syndrome in premature infants
Reyna-Ríos ER, Fernández-Carrocera LA, Salinas-Ramírez V, Echaniz-Avilés O, Romero-Maldonado S
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ABSTRACTIntroduction: Respiratory distress syndrome (RDS) is the principal respiratory problem in premature infants with high morbidity and mortality, due to immaturity and lack of production of pulmonary surfactant. Objective: Establish differences (incidence of RDS, intraventricular hemorrhage, broncopulmonar dysplasia, ventilation time and death) in the profilactic treatment between two types of natural surfactant (porcine and bovine) in preterm infants. Material and methods: Cross sectional, retrospective and analytic study from July 2005 to July 2006. The inclusion criteria were: birth weight between 600- 1250 g, gestational age less than 32 weeks, orotraqueal intubation and hemodynamic stability, included in two groups: group 1 (poractant alfa 200 mg/kg/doses) and group 2 (beractant 100 mg/kg/doses). Birthweight, gestational age, FiO2, ventilation time, RDS, BPD, intraventricular hemorrhage, ROP and mortality were analysed. Statistical analysis was done with SPSS 15, using, depending the type of variable, chi cuadrada, t de Student, U de Mann-Whitney and OR (CI 95%). Results: In the poractant alfa group there were 74 cases, and beractant group 80. The requirement of FiO2, ventilation time, cases of RDS, DBP, ROP, and the association of RDS with mortality were less for poractant alfa group, and they only received one dosis in the 83% of the cases. These differences were statistical significant. Conclusions: The use of poractant alfa reduces the risk of developing RDS, the percentage of FiO2 required, hours of mechanical ventilation and BPD, as well as the need for further doses.