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Organo Oficial de la Sociedad Mexicana de Urología

2012, Number 1

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Rev Mex Urol 2012; 72 (1)

Human papillomavirus detection through polymerase chain reaction in penile cancer patients: experience at the Urology Department of the Hospital General “Dr. Manuel Gea González”

Muñoz-Ibarra EL, Santana-Ríos Z, Fulda-Graue S, Pérez-Becerra R, Urdiales-Ortiz A, Fernández-Noyola G, Martínez Á, Ahumada S, García-Salcido F, Camacho-Castro A, Mayorga-Gómez E, Garza-Saenz G, Osornio-Sánchez V, Cantellano-Orozco M, Morales-Montor G, Pacheco-Gahbler C

Language: Spanish
References: 16
Page: 8-12
PDF size: 426.46 Kb.


ABSTRACT

Introduction: Carcinoma of the penis is a rare tumor and little is known about the role human papillomavirus plays in this type of cancer. In the last few years this virus has been recognized as a possible etiologic agent in penile cancer. Cytologic changes suggestive of human papillomavirus infection are similar to those observed in women (koilocytosis, dyskeratocytosis, and nuclear changes). The mechanism by which human papillomavirus makes a malignant transformation is probably through the E6 and E7 viral genes. These form products of the p53 and pRb suppressor genes, resulting in uncontrolled cell proliferation. Basaloid and verrucous histological subtypes are the most frequently related. A 30.5% prevalence has been shown in paraffin-embedded samples using polymerase chain reaction.
Objective: To evaluate the presence of human papillomavirus through the polymerase chain reaction technique in samples from nineteen patients with invasive penile cancer that were reviewed within the time frame of 2000 to 2011, as well as to identify the most frequent human papillomavirus genotypes.
Material and methods: Within the time frame of 2000 to 2011, 19 paraffin-embedded samples with histopathologic report of penile cancer were reviewed. Diagnosis was made according to clinical history, physical examination, and biopsy.
Results: Deoxyribonucleic acid for human papillomavirus was detected in seven of the nineteen samples studied (36.8%) and genotypes 16, 18, and 32 were identified.
Conclusions: The present series showed an association with human papillomavirus infection in 37% of the penile cancer patients studied.


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