medigraphic.com
ISSN 1561-297X (Print)

2011, Number 4

<< Back Next >>

Rev Cubana Estomatol 2011; 48 (4)

Histopathological characterization in the leukoplakia buccalis in Havana during 10 years

Batista CZ, Rodríguez PI, Miranda TJ, Rengifo CE, Rodríguez OT, Fernández JME

Language: Spanish
References: 27
Page: 330-340
PDF size: 418.09 Kb.


ABSTRACT

The epithelial dysplasia is considered the stronger predictor of a future malignant transformation of the leukoplakia buccalis. The aim of present paper was to determine the presence and severity of this type of dysplasia and its association with the histological alterations of epithelial and connective tissues of mucosa in the leukoplakia buccalis. A cross-sectional and descriptive research was conducted in 83 biopsies processed by technique of paraffin inclusion and stained with Hematoxylin and Eosin of patients diagnosed with this entity between 1991-2001 from the Stomatology Faculty of the Medical Sciences University of La Habana. The 92.8 % of patients with a clinical diagnosis of leukoplakia buccalis had slight epithelial dysplasia, from these and according to its grade of severity, there was found a slight epithelial dysplasia in the 53.0 %, moderate epithelial dysplasia in the 36.4 % and a severe epithelial dysplasia in 10.4 %. The parakeratosis was manifested in the 43.9 % associated with a slight epithelial dysplasia, 78.6 % with a moderate dysplasia and in the 100 % with the severe one. The epithelial dysplasia was present in the 57.1 % of cases and the inflammatory infiltrate in the 79.2 % of study samples. Authors conclude that in the study sample of leukoplakia buccalis there is a high percentage of epithelial dysplasia with predominance of its slight degree and a association between its severity degree with the different patterns of keratinization and the intensity of inflammatory infiltrate, something important in the analysis of its course in face a determined diagnosis y its prognosis.


REFERENCES

  1. Slama BL. Potentially malignant disorders of the oral mucosa: terminology and classification. Rev Stomatol Chir Maxillofac. 2010;4:208-12.

  2. Petersen PE. Strengthening the prevention of oral cancer: the who perspective. Community Dent Oral Epidemiol. 2005;33(6):297-9.

  3. Miranda J, Fernández L, García G, Rodríguez I, Trujillo E. Pacientes remitidos por el Programa de Detección de Cáncer Bucal. Facultad de Estomatología de La Habana, 1999-2006. Rev Cubana Estomatol. 2010;47(4):381-91.

  4. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol. 2010;46(6):423-5.

  5. Warnakulasuriya S, Johnson NW, Van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575-80.

  6. Santana JC. Prevención y diagnóstico del cáncer bucal. La Habana: ECIMED; 2002. p. 42-9.

  7. Wang YF, Shang S, Zhou ZT, Tang GY. A retrospective analysis on the malignant transformation rate, time and risk factors of oral leukoplakia. Shanghai Kou Qiang Yi Xue. 2011;1:55-61.

  8. Pindborg JJ, Reichart CJ. Who histological typing of cancer and precancer of the oral mucosa. New York: Springer; 1997.

  9. Amagasa T, Yamashiro M, Uzawa N. Oral premalignant lesions: from a clinical perspective. Int J Clin Oncol. 2011;1:5-14.

  10. Speight MP. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol. 2007;1:616.

  11. Rodiles H, Campañón JL, Laza C. Citohistopatología. Procedimientos básicos. La Habana: ECIMED; 2008.

  12. Smith CJ, Pindborg JJ. Histological grading of oral epithelial atypia by the use of photographic standards. Dep of Oral Pathology. Copenhagen: Royal Dental College Ed; 1969.

  13. Fernández ME, Rodríguez I, Miranda J, Batista Z. Displasia epitelial como característica histopatológica del liquen plano bucal. Rev Haban Cienc Med. [serie en internet]. 2009 [citado: 30 may 2011];8(4): [aprox. 1 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729519X2009000400003&lng=es

  14. Smith CJ, Renstrup G. The cronic inflammatory cell reactions associated with oral leukoplakia. Meeting Investigation Oral Pre-cancer. Bombay, La India. 1970.

  15. Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological and molecular biological characteristics. Crit Rev Oral Biol Med. 2003;14(1):47-62.

  16. Álvarez VR, González FF, Vila GP, López RD, García GA, Rey GJ. Correlation between clinical and pathologic diagnosis in oral leukoplakia in 54 patients. Med Oral Patol Oral Cir Bucal. 2010;6:832-8.

  17. Rodríguez I, Bánoóczy J. Oral leukoplakia: a histopathological study. Acta Morphologica Acad Sci Hung. 1982;30(3-4):289-98.

  18. Pereira JS, Carvalho MV, Henriques AC, de Queiroz CT, Miguel MC, Freitas RA. Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases. Ann Diagn Pathol. 2011;2:98-102.

  19. Warnakulasuriya S. Histological grading of oral epithelial dysplasia: revisited. J Pathol. 2001;194(3):294-7.

  20. Wang Z, Feng X, Liu X, Jiang L, Zeng X, Ji N, et al. Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis. BMC Genomics. 2009;10:383.

  21. Otero I, Rodríguez I, Travieso M, González G, Hidalgo-Gato I. Estudio histopatológico del epitelio de la leucoplasia bucal. Rev de Ciencias Médicas de Pinar del Río. 2003;7(2):1561-3194.

  22. Ríos M, Rodríguez I, Miranda J, Mandado S. Correlación entre la coilocitosis y la leucoplasia bucal. VIII Congreso Virtual Hispanoamericano de Patología, 2006. Disponible en: http://conganat.cs.urjc.es

  23. Programa Nacional de Atención Estomatológica Integral a la Población. República de Cuba. Ministerio de Salud Pública. Área de Asistencia Médica y Social. Dirección Nacional de Estomatología, La Habana, Cuba. [serie en internet]. 2002 [citado: 20 abr 2007]. Disponible en: http://aps.sld.cu/bvs/materiales/programa/otros/estomatologia/programanacional.pdf

  24. Hunter T, Pustzal L. Neoplasias. En: Cotran RS, Kumar MD, Path GR, Collins T. Robins: patología estructural y funcional. Boston: Mc Graw-Hill-Interamericana; 2007. p. 778-80.

  25. Lehner T, Shillitos E. Aspectos inmunológicos del cáncer. En: Fundamentos científicos de la odontología. La Habana: Ed. Científico Técnica; 1983. p. 204.

  26. Pillai R. Immunological abnormalities in oral precancer. Cancer Lett. 1991;57:1.

  27. Albornoz C, Rivero O, Bastian L. Avances en el diagnóstico de las lesiones cancerizables y malignas del complejo bucal. AMC. [serie en internet]. 2010 [citado: 6 may 2011];14(5): [aprox. 1 p.]. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1025-02552010000500019&script=sci_arttext




2020     |     www.medigraphic.com