2009, Number 4
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ABSTRACTTuberculosis is among the leading causes of death worlwide. One third of the world population is infected with Mycobacterium tuberculosis. Drug resistance to isoniazid and rifampin, the 2 most potent first-line drugs for the treatment of TB (the definition for MDRTB), is increasing globally. MDRTB is caused by the sequential acquisition of single resistance trials. This has been a consequence de poor prescribing practice by doctors, patient non-compliance with treatment ant the endogenous mutation of M. tuberculosis. Previous treatment for TB has been identified as an important risk factor for the acquisition of drug-resistant TB. The treatment of the MDRTB is difficult and may necessitate the use of second-line drugs or resectional surgery. Therefore, the management of patients should only be undertaken by, or in very close contact with, experts in this area. The individualized treatments are expensive and they are so difficult to implement in middle-low countries, which bear the highest burden of MDRTB cases. For this reason, the 1996 WHO recommendations for the treatment of MDRTB favored the use of standardized treatments in specific circumstances. The treatment of the XDRTB always has be individualized.
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