Gaceta Médica de México

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Gaceta Médica de México >Year 2009, Issue 4

Manfredi R
A woman with multiple autoimmune diseases: pathologic correlations and complications
Gac Med Mex 2009; 145 (4)

Language: Inglés
References: 13
Page: 347-348
PDF: 37.34 Kb.

Full text


A very uncommon case report of a young woman suffering from multiple autoimmune-dysreactive disorders (including thyroiditis, myasthenia gravis, Crohn’s disease, and erythema nodosum), while undergoing steroideal therapy, was complicated by a severe upper urinary tract infection. The pathogenetic and clinical association between the different autoimmune-dysreactive complications deserves discussion, as well as the eventual supporting role of the immunosuppressive treatment, which might contribute significantly to these risk factors. Clinicians who are engaged in the management of these patients should be aware that multiple, concurrent or subsequent disorders may occur in these subjects, and also severe infectious complications may be of relevant concern.

Key words: Thyroiditis, myasthenia gravis, thymectomy, Crohn’s disease, erythema nodosum, autoimmunity, systemic infectious complications.


  1. Alarcón-Segovia D, Galbraight RF, Maldonado JE, Howard FM Jr. Systemic lupus erythematosus following thymectomy for myasthenia gravis. Report of two cases. Lancet 1963;ii:662-665.

  2. Galbraight RF, Summerskill WH, Murray J. Systemic lupus erythematosus, cirrhosis and ulcerative colitis after thymectomy for myasthenia gravis. N Engl J Med 1964;270:229-231.

  3. Miller TN. Myasthenia gravis, ulcerative colitis and lichen planus. Proc R Soc Med 1971;64:807-808.

  4. Souadjian JV, Enríquez P, Silverstein MN, Pépin JM. The spectrum of diseases associated with thymoma. Arch Intern Med 1974;134:374-379.

  5. McCann P, Pramarik A. Dysphagia and unexpected myasthenia gravis associated with primary cirrhosis, ulcerative colitis and vitiligo. J Am Geriatr Soc 2004;52:1407-1408.

  6. Foroozan R, Sambursky R. Ocular myasthenia gravis and inflammatory bowel disease: a case report and literature review. Br J Ophthalmol 2003;87:1186-1187.

  7. Bach JF. Infections and autoimmune diseases. J Autoimmun 2005;25(Suppl): 74-80.

  8. Bansal AS, Ollier W, Marsh MN, Pumphrey RS, Wilson PB. Variations in serum cCD23 in conditions with either enhanced humoral or cell-mediated immunity. Immunology 1993;79:285-289.

  9. Martin RW, Shah A. Myasthenia gravis coexistent with Crohn’s disease. J Clin Gastroenterol 1991;13:112-113.

  10. Finnie IA, Shields R, Sutton R, Donnelly R, Morris AI. Crohn’s disease and myasthenia gravis: a possible role for thymectomy. Gut 1994;35:278-279.

  11. Mizuno Y, Muraoka M, Shimabukuro K, Toda K, Miyagawa K, Yoshimatsu H, Tsuchiya A. Inflammatory bowel diseases and thymus disorder: reactivity of thymocytes with monoclonal antibodies. Bull Tokyo Dent Coll 1990; 31:137-141.

  12. Aiso S, Yoshida T, Watanabe M, Hibi T, Asakura H, Tsuchiya A, Tsuru S. J Clin Lab Immunol 1984;13:137-138.

  13. Yokono H, Hibi T, Fujisawa T, Suzuki T, Ohbu M, Muraoka M, Tsuchiya M, Hata J. Immunohistochemical study of thymic B cells in myasthenia gravis and ulcerative colitis. Acta Patol Jpn 1993;43:386-395.

>Journals >Gaceta Médica de México >Year 2009, Issue 4

· Journal Index 
· Links 

Copyright 2019