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2011, Number 4

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Rev Cubana Farm 2011; 45 (4)

Aspirin desensitization in a patient who exhibit intolerance to non-steroidal anti-inflammatories

Álvarez CM, Osoria ML, Ronquillo DM, Castro ARL, Pérez MD, Rodríguez CJS, Irarragorri TC

Language: Spanish
References: 17
Page: 597-603
PDF size: 44.72 Kb.


ABSTRACT

Aspirine is one of the most widely used drugs worldwide. The patients suffering from heart diseases require long-term treatment with this drug, which is banned to those having adverse reactions. The international literature collects information on the use of desensitization therapies in patients who do not exhibit tolerance to this medicine, following different protocols with satisfactory results. This paper described the first aspirin desensitization procedure, which was performed at «Calixto García» university hospital, and the performance protocol. There was not any other case of this type reported in the national literature. The patient can presently take 125 mg of aspirin daily without suffering adverse events. It was considered that the desensitization process is an effective therapeutic action for patients who are aspirin sensitive and who have specific diseases that warrant this procedure.


REFERENCES

  1. Dalmau G, Gaig P, Gázquez V y Mercé J. Desensibilización rápida al ácido acetilsalicílico en pacientes con intolerancia a AINE afectos de síndrome coronario agudo. Rev Esp Cardiol [Internet]. 2009 [citado 10 de May 2011]; 62(2):224-30. Disponible en: http://www.revespcardiol.org/es/revistas/revista-espa%C3%B1olacardiologia-25/desensibilizacion-rapida-al -acido-acetilsalicilico-pacientes-intolerancia-13132057-cartas-al-editor-2009

  2. Shome GP, Tarbox J, Shearer M, Kennedy R. Cytokine expression in peripheral blood lymphocytes before and after aspirin desensitization in aspirin-exacerbated respiratory disease. Allergy Asthma Proc. 2007;28:706-10.

  3. Moreno-Brea MR. Tolerabilidad de aspirina. Rev Soc Esp Dolor [Internet]. 2005 [citado 5 May 2011]; 12(6):357-72. Disponible en: http://scielo.isciii.es/pdf/dolor/v12n6/revision2.pdf

  4. A. Rozsasi D, Polzehl T, Deutschle E, Smith K, Wiesmiller H. Riechelmann, et al. Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily. Allergy [Internet]. 2008 [cited 2011 May 12]; 63:1228-34. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2008.01658.x/full

  5. Wong JT, Nagy CS, Krinzman SJ, Maclean JA, Bloch KJ. Rapid oral challengedesensitization for patients with aspirin related urticaria-angioedema. J Allergy Clin Immunol [Internet]. 2000 [cited 2011 May 12]; 105:997-1001. Available from: http://www.jacionline.org/article/S0091-6749%2800%2980024-X/fulltext

  6. Rachel U, Donald L, Stevenson D. Aspirin-Exacerbated Respiratory Disease: Evaluation and Management. Allergy Asthma Immunol Res [Internet]. 2011 January [cited 2011 Mar 12]; 3(1):3-10. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005316/

  7. Ortega-Loayza AG, Raza S, Minisi AJ, Topaz O, Heller A, Jovin I. Aspirin Desensitization/Challenge in 3 Patients With Unstable Angina. Am J Med Sci [Internet]. 2010 [cited 2011 Apr 12]; 340(5):418-20. Available from: http://journals.lww.com/amjmedsci/Abstract/2010/11000/Aspirin_Desensitization_Challenge_in_3_Patients.18.aspx

  8. AL De Weck, ML Sanz, Gamboa PM, Aberer W, Blanca M, Correia S, et al. Nonsteroidal Anti-inflammatory Drug Hypersensitivity Syndrome. A Multicenter Study. Clinical Findings and in vitro Diagnosis. J Investig Allergol Clin Immunol [Internet]. 2009 [cited 2011 Mar 12]; 19(5):355-69. Available from: http://www.jiaci.org/issues/vol19issue5/2.pdf

  9. Lee RU, Stevenson DD. Aspirin-Exacerbated Respiratory Disease: Evaluation and Management. Allergy Asthma Immunol Res [Internet]. 2011 [cited 2011 Mar 12]; 3(1):3-10. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005316/

  10. Gollapudi R. Sensibilidad a la aspirina y posibilidades de desensibilización. JAMA [Internet]. 2004 [citado 5 May 2011]; 292:3017-23. Disponible en: http://www.foroaps.org/files/sensibilidad%20a%20la%20aspirina.pdf

  11. Stevenson DD, Simon RA. Sensitivity to aspirin and nonsteroidal antiinflammatory drugs. In: Middleton EJr, Ellis EF, Yunginger JW, Reed CE, Adidnson NF Jr, Busse WW, editors. Allergy principles and practice. 5th ed. St Louis: Mosby; 1998. p. 1225-34.

  12. Grzelewska-Rzymowska I, Roznlecld J, Szmidt M. Aspirin desensitization in patients with aspirin-induced urticaria and angioedema. Allergol Immunopathol [Internet]. 1988 [cited 2011 May 12]; 16:305-8. Available from: http://ukpmc.ac.uk/abstract/MED/3228050

  13. Asad SI, Kemeny DM, Youlten LJF, Frankland AW, Lessof MH. Effect of aspirin in «aspirin sensitive» patients. BMJ [Internet]. 1984 [cited 2011 Apr 15]; 288:745-8. Available from: http://www.bmj.com/content/288/6419/745.full.pdf

  14. Stevenson D, Simon RA. Selection of patients for aspirin desensitization treatment. J Allergy Clin Immunol [Internet]. 2006 [cited 2011 Apr 11]; 118:801-4. Available from: http://download.journals.elsevierhealth.com /pdfs/journals/0091-6749/PIIS0091674906019117.pdf

  15. Cardona R, Ramírez RH, Reina Z, Escobar M F, Morales E. Alergia e intolerancia a antiinflamatorios no esteroideos: desensibilización exitosa en tres casos y revisión de la literatura. Biomédica [Internet]. 2009 [citado 21 May 2011]; 29;181-90. Disponible en: http://www.scielo.org.co/pdf/bio/v29n2/v29n2a03.pdf

  16. Stevenson DD, Szczeklik A. Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol [Internet]. 2006 [cited 2011 Apr 17]; 118(4):773-86. Available from: http://www.jacionline.org/article/S0091-6749%2806%2901570-3/fulltext

  17. Shaker M, Lobb A, Jenkins P, O'Rourke D, Takemoto SK, Sheth S, Burroughs T, Dykewicz MS. An economic analysis of aspirin desensitization in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol [Internet]. 2008 [cited 2011 Mar 12]; 121:81-7. Available from: http://www.jacionline.org/article/S0091-




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