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Revista Cubana de Farmacia

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2011, Number 3

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Rev Cubana Farm 2011; 45 (3)

Filtration time for calcium cytrate and magnesium from the Cuban dolomite

Rodríguez CJE, López HOD
Full text How to cite this article

Language: Spanish
References: 10
Page: 449-453
PDF size: 101.92 Kb.


Key words:

calcium and magnesium citrate, filtration, filtration time, dolomite.

ABSTRACT

Calcium and magnesium citrate is a raw material of pharmaceutical quality obtained from Cuban dolomites to be used in those people with deficiency in these two minerals. As part of the technological process optimization, the filtering time was studied to evaluate the possible behaviour at higher scales. To this end, one scaledown study was made to determine the conditions at bench scale by keeping the same power consumption per volume unit. The fundamental filtering equation allowed determining the time for this operation. The results of this study showed that the resistance value of the filtering material was Rm= 6.08 · 1010 m-1 and the resistance of the mass was α= 1.239 · 1010 m·kg-1 at constant pressure (Δp= 9.99 × 104 kg/m·s2). The filtration time was 494.6 s (8,24 ± 3,0 min). The results showed that the filtration time was correct for the studied technological process and the scale up study demonstrated the feasibility of the filtration process.


REFERENCES

  1. Rodríguez Chanfrau, JE, Graveran T, Rodríguez I, Díaz I, Roberto Y, Mateus L, et al. Proceso de obtención de citrato de calcio y magnesio a partir de dolomita. Patente CO1F 1/00; A61K 33/06, A61K 9/00, C07C 51/41. Certificado 22794. 2002.

  2. Vian A, Ocon J. Elementos de Ingeniería Química. Cap. 14 y 17. La Habana: Ed. Pueblo y Educación; 1977. p. 389-424; 479-514.

  3. González Castellano RA. Principios básicos de escalado. La Habana: Ed. Universitaria; 2000. p. 9-18.

  4. Granges Brown G. Operaciones básicas de Ingeniería Química. La Habana: Ed. Revolucionaria; 1967. p. 592-5.

  5. Jáuregui Haza U, Pérez Carpio C, Pellón Comdom R, Márquez Conde T, Suárez Valdés-Ayala A. Filtración al vacío del Lobenzarit. Rev Cubana Farm. 1995;29(2):82-86.

  6. McCabe W, Smith JC. Unit Operations of Chemical Engineering. La Habana: Ed. Revolucionaria; 1979. p. 933.

  7. Svarovsky L. Solid-Liquid Separation. 4th ed. Oxford: Ed. Butterworth-Heinemann; 2000. p. 335-48; 409-25.

  8. Rosabal J, Valle M. Hidrodinámica y separaciones mecánicas. Tomo II. La Habana: Ed. Pueblo y Educación; 1977. p. 152-94.

  9. Rodríguez Chanfrau JE, López Hernández OD, Nogueira Mendoza A. Secado del citrato de calcio y magnesio a escala de banco. Rev Cubana Farm 2009;43(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75152009000100004&lng=es

  10. Rodríguez Chanfrau JE, Lagarto Parra A, Bueno Pavón V, Guerra Sardina I, Vega Hurtado Y. Eficiencia del proceso de lavado en la obtención del citrato de calcio y magnesio a escala de banco. Rev Cubana Farm. 2010;45(1):5-12. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152010000100002&lng=es




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Rev Cubana Farm. 2011;45