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ISSN 1561-3011 (Electronic)

2011, Number 1

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Rev Cubana Invest Bioméd 2011; 30 (1)

Implementation of reaction-diffusion systems in the design of the internal geometry of matrices for bone regeneration

Garzón ADA, Velasco PMA

Language: Spanish
References: 26
Page: 83-96
PDF size: 576.12 Kb.


ABSTRACT

One of the different areas of textile Engineering is the search of alternatives to create a new bone tissue and the replacement of its function. To fulfill this requirement different matrices have been developed allowing the cellular migration, the growth of bone tissue, the transportation of growth factors and nutrients, as well as the renewal of bone mechanical properties. Matrices are manufactured through different techniques that in some cases, to obstruct the total control on the size and orientation of characteristic pores. From this perspective, authors propose a reaction-diffusion system to design the geometrical specifications of bone matrices. To assess the hypothesis simulations are performed in two or three dimensions of reaction-diffusion system together with the biomaterial to create the matrix. Results obtained show the effectiveness of the methodology to control the following features: porosity percentage, pore size, orientation and interconnection of these bone matrices manufactured according the proposed hypothesis.


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