2012, Number 601
Kawer WA, Madrigal RL, Mata CF
PDF size: 553.26 Kb.
ABSTRACTAmyloidosis disease is rarely present in head and neck. The larynx is the human organ most affected, specially in the supraglotic area. Different presentations of Amyloidosis are considered between physicians, like the localization and the differential diagnosis. Finally the biopsy is the only valid method to establish the positive diagnosis. The amyloid substance is a fibrilar proteinic material that deposits in the tissues´ extracellular space, principally in ones mesoderm derivates. The etiology of amyloidosis remains unknown, and there is no definitively established link with smoking, vocal abuse, or recurrent infections. Symptoms can be presented as dysphonia, diplophonia, whisper o shortness of breath.
The most effective treatment currently available for organlimited laryngeal amyloidosis is microdirect laryngoscopy with excision.