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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2012, Number 06

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Ginecol Obstet Mex 2012; 80 (06)

Anti-Ro/SSA Antibodies in Congenital Heart Block

Barrios PE, Martínez CDA, Panduro BJG, Fajardo DS
Full text How to cite this article

Language: Spanish
References: 11
Page: 417-420
PDF size: 228.23 Kb.


Key words:

congenital heart block, anti-Ro/SSA, congenital heart disease.

ABSTRACT

Describe a case of a female patient having anti-Ro/SSA antibodies without any other risk factor or collagen disease. In her first pregnancy a congenital heart block and hydrops in the fetus were diagnosed, and these caused stillbirth. In a second pregnancy an in utero treatment resulted in the succesful delivery of a normal child.


REFERENCES

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  2. Cavazzana I, Franceschini F, Belfiore N, et al. Undifferentiated connective tissue disease with antibodies to Ro/SSA: Clinical features and follow-up of 148 patients. Clin Exp Rheumatol 2001;19:403.

  3. Phan TG, Wong RC, Adelstein S. Autoantibodies to extractable nuclear antigens: Making detection and interpretation more meaningful. Clin Diagn Lab Immunol 2002;9:1.

  4. Buyon JP, Hiebert R, Copel J et al. Autoinmmune associated congenital heart block: Demographics, mortality, morbidity and recurrence rates obtained from de national lupus registry. J Am Coll Cardiol 1998;31:1658-1656.

  5. Jaeggi ET, Fouron JC, Silverman ED et al. Transplacental treatment improves the outcome of prenatally diagnosed complete atriventricular block without structural heart disease. Circulation 2004;110:1542-1548.

  6. Jaeggi ET, hamilton RM, Silverman ED et al. Outcome of children with fetal, neonatal or childhood diagnosis of isolated complete heart block. A single institution’s experience of 30 years. J Am Coll Cardiol 2002;39:130-137.

  7. Salmonsson S, Sonesson SE, Ottosson L et al. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis and mediate congenital heart block. J Exp Med 2005;201:11-17.

  8. Rivera TL, Izmirly PM, Birnbaum BK et al. DIsease progresión in mother of children enrolled in the research registry for neonatal lupus. Ann Rheum Dis 2009;68:828.

  9. Ramsey-Goldman R, Hom D, Deng JS et al. Anti-SSA antibodies and the fetal outcome in maternal systemic lupus erythematosus. Arthritis Rheum 1986;29:1269-1273.

  10. Boutjdir M. Molecular and ionic basis of congenital complete heart block. Trends Cardiovasc Med 2000;10;114-122.

  11. Friedman DM, Kim MY, Copel JA et al. Prospective evaluation of fetuses with autoinmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) study. Am J Cardiol 2009;03:1102.




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C?MO CITAR (Vancouver)

Ginecol Obstet Mex. 2012;80