2012, Number 2
Anti glycosylation effect of vitamin C and E in diabetic patients vs placebo
Castellanos CL, Sánchez VL, Hernández ANJ, Rodríguez LL, Rubio GAF, Melchor LA
Full text
Language: Spanish
References: 7
Page: 112-116
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ABSTRACT
Background: Diabetes Mellitus with its chronic complications is a major cause of morbidity and mortality. It has come to chronic hyperglycemia as the condition responsible for the development of chronic complications.Methods: Randomized controlled trial. We included 70 patients diagnosed with type 2 diabetes mellitus. 35 patients received placebo and 35 patients were treated with vitamin C and E at a dose of 2 g and 200UI respectively. For statistical analysis we used mean, standard deviation, U-Mann-Whitney and t-Student.
Results: The mean age for the placebo group was 55.77 years and for group of vitamin C and E of 54.23 years, with statistically significant difference p 0.018 (95% 0.963-10.12, p ‹0.05). The most widely used drug treatment in both groups was the concomitant administration of glibenclamide and metformin. As for glycated hemoglobin levels the differences after of 3 month follow-up was mean 7.7% for placebo group and 6.9% for vitamin C and E with p 0.004 (95% CI 0.28 - 1.41, p ‹0.05). As for other study variables were differences in systolic blood pressure values with an mean of 131 mmHg and 125 mmHg for placebo group and group with intake of vitamin C and E, respectively (95% 0.741-10.40, p ‹0.05).
Conclusion: The administration of vitamin C and E as adjuvant treatment of patients with diabetes reduces glycated hemoglobin levels and systolic blood pressure levels.
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