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Colegio de Medicina Interna de México.

2012, Number 3

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Med Int Mex 2012; 28 (3)

Vitamin D in critically ill patients. Current concepts

Carrillo ER, Zárate VV

Language: Spanish
References: 55
Page: 262-268
PDF size: 485.81 Kb.


ABSTRACT

Vitamin D is a fat-soluble vitamin with pleiotropic effects in inmmunity, endotelial and mucosal functions and in glucose and calcium metabolism. Tissue demand for vitamin D increase during infection, metabolic disturbances and inflammation. Vitamin D deficiency is rarely considered or treated in critically ill patients, but recent studies in the intensive-care unit reveals a high prevalence of hipovitaminosis D associated with increase of mortality and adverse outcomes. The cause of hipovitaminosis D in the critically ill is probably secondary to limited exposure to sunlight and altered vitamin D and parathyroid metabolism. Vitamin D supplementation is necessary in the critically ill but failure of conventional vitamin D supplementation in correcting deficiency has called for studies to evaluate the efficacy and safety of a highdose regime in critically ill patients. The aim of this paper is to review de current concepts relating to the role of vitamin D in the critically ill.


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