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2012, Number 2

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Med Cutan Iber Lat Am 2012; 40 (2)

Iatrogenic Cushing’s syndrome caused by topical steroid therapy in two adults

Casado-Verrier B, Sanz-Canalejas L, Gómez-Fernández C, Pagán B, López M, Casado-Jiménez M
Full text How to cite this article

Language: Spanish
References: 13
Page: 58-61
PDF size: 83.45 Kb.


Key words:

Topical corticosteoid, Cushing syndrome iatrogenic.

ABSTRACT

Topical corticosteroids are the mainstay of treatment for many non-infectious dermatoses. If used appropriately they are a safe and effective therapy, but without medical supervision severe local and systemic adverse effects may occur. We report two patients followed at our Dermatology unit that developed iatrogenic Cushing´s syndrome after using topical corticosteroids. Although it´s an extremely rare complication in adults, we must be aware of this adverse effect in patients with chronic inflammatory dermatoses, as diagnosis requires a high grade of suspicion.


REFERENCES

  1. Hengge UR, Ruzicka T, Schwartz R, Cork MJ. Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol 2006; 54: 1-15.

  2. Gilbertson EO, Spellman MC, Piacquadio DJ, Mulford MI. Super potent topical corticosteroid use associated with adrenal suppression: Clinical considerations. J Am Acad Dermatol 1998; 38: 318-21.

  3. Olsen EA, Cornell RC, Topical clobetasol-17- propionate: Review of its clinical efficacy and safety. 1986; 15: 246-55.

  4. Ohman EM, Rogers S, Meenan FO, McKenna TJ. Adrenal suppression following lowdose topical clobetasol propionate. J R Soc Med 1987; 80: 422-4.

  5. Staughton CD, August PJ, Cushing’s syndrome and pituitary-Adrenal suppression due to clobetasol propionate. BMJ 1975; 2: 418-21.

  6. Curtis JA, Cormode E, Laski B, Toole J, Howard N. Endocrine complications of topical and intralesional corticosteroid therapy. Arch Dis Child 1982; 57: 204-7.

  7. Abma EM, Blanken R, De Heide LJ M. Cushing’s síndrome caused by topical steroid therapy for psoriasis. Neth J Med 2002; 60: 148-50.

  8. Ermis B, Ors R, Tastekin A, Ozkan B. Cushing’s syndrome secondary to topical corticosteroids abuse. Clin Endocrinol 2003; 58: 795-7.

  9. Augey F, Dissard C, Normand I, Daumont M. generalized pustular psoriasis (von Zumbusch) following iatrogenic hypocortisolism. Eur J Dermatol 2004; 14: 415-7.

  10. Gen R, Akbay E, Sezer K. Cushing syndrome caused by topical corticosteroid: a case report. Am J Med Sci 2007; 333: 173-4.

  11. Atabek ME, Pirgon O, Unal E. Pituitary-adrenal axis suppression due to topical steroid administration in an infant. Pediatr Int 2007; 49: 242-4.

  12. Boscaro M, Barzon L, Sonino N. The diagnosis of Cushing’s syndrome. Arch Intern Med 2000; 160: 3045-53.

  13. Bewley A. on behalf of the Dermatology Working Group. Expert consensus: time for a change in the way we advise our patients to use topical corticosteroids. Br J Dermatol 2008; 158: 917-20.




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Med Cutan Iber Lat Am. 2012;40