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Revista Cubana de Plantas Medicinales

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2011, Number 4

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Rev Cubana Plant Med 2011; 16 (4)

Caracterización del triterpeno cicloartanol aislado del extracto de dicloromentano de Pedilanthus tithymaloides

Cabrera SH, Cuellar CA, Pita RC
Full text How to cite this article

Language: English
References: 15
Page: 347-353
PDF size: 98.27 Kb.


Key words:

cicloartanol, Pedilanthus tithymaloides, ítamo real, triterpenos, fitoquímica.

ABSTRACT

Introduction: Pedilanthus tithymaloides is known as ítamo real and it has been previously reported as an alternative to treatment of oral cavity virus infections.
Objective: to explain procedures to characterize one of the major compounds isolated from dichloromethane extracts of Pedilanthus tithymaloides (L.) Poit (leaves).
Methods: it was obtained cycloartanol from dichloromethane extract modifying polarity of the solvents with methanol and by increasing polarity to extract, they were used chromatography technique and spectroscopic of nuclear magnetic resonance H+ and 13C to characterize this compounds.
Results: phytochemical studies showed quality parameters that were similar to average limits in the use of majority of medicinal plants except total ashes assay (13 %), qualitative determination assay suggest presence of reducers compounds, quinone, phenols and/or tannins, triterpene and/or steroids. And they were compared spectrum carbon 13 (13C) of the substance obtained from extract of this plant with other reported in literature to cycloartanol and found coincidence in majority of carbons compared. Conclusions: cycloartanol triterpene was one of main compounds of dichloromethane extract of Pedilanthus tithymaloides (L) Poit leaves.


REFERENCES

  1. Cuba. Ministerio de Salud Pública. Plantas Medicinales (Fitomed III). La Habana: Editorial Ciencias Médicas; 1994. p. 34-5.

  2. Roig JT. Diccionario botánico de nombres vulgares cubanos. La Habana: Editorial Científico-Técnica; 1974.

  3. Beltrán A, Cuellar A. Evaluación antitumoral del látex de la planta ítamo real [Tesis de Diploma]. IFAL: Universidad de La Habana; 1999.

  4. Roig JT. Diccionario botánico de nombres vulgares cubanos. 3ra ed. La Habana; 1962. p. 1092-3.

  5. Cabrera Suárez H, Núñez Figueredo. Efecto sedante del triterpeno cicloartanol obtenido de las hojas de Pedilanthus tithymaloides (L.) Poit. Rev Cubana Plant Med [online]. 2010[citado 21 May 2011];15(3):96-104 . Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028- 47962010000300001&lng=es&nrm=iso ISSN 1028-4796.

  6. Rojas G, Aranda E, Navarro V, Zamilpa A, Tortoriello J. In vitro propagation of Galphimia glauca and content of the sedative compound galphimine-B in wild and micropropagated plants. Planta Med. 2005;71(11):1076-8.

  7. Amos S, Orisadipe A, Binda L, Emeje M, Adesomoju A, Okogun J, et al. Behavioural effects in rodents of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense. Pharmacol Toxicol. 2002;91(2):71-6.

  8. Osuna L, Pereda-Miranda R, Tortoriello J, Villarreal ML. Production of the sedative triterpene galphimine B in Galphimia glauca tissue culture. Planta Med. 1999;65(2):149-52.

  9. Tortoriello J, Ortega A. Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca. Planta Med. 1993;59(5):398-400.

  10. Sánchez Govín E, Pérez Lamas AM, Chávez Figueredo D, Hechevarría Sosa I. Caracterización farmacognóstica de Pedilanthus tithymaloides L. Poit. Rev Cubana Plant Med [serie en Internet]. 2005 Abr [citado 02 Oct 2011];10(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028- 47962005000100004&lng=es

  11. Cuellar A, Miranda M. Farmacognosia y productos naturales. La Habana: Editorial Félix Varela; 2001. p. 207-13.

  12. Satyajit D. Sarker, Zahid Latif, Alexander I. Gray Natural Products Isolation 2nd ed. New Jersey: Human Press Inc.; 2006. ISBN 1-59259-955-9

  13. Bhakuni DS, Rawat DS. Bioactive Marine Natural Products. New York: Ed. Springer; 2005. p. 64-13. ISBN 1-4020-3484-9 (e-book).

  14. Wehr T, Rodriguez Diaz R, Tuck S. Analytical techniques for biopharmaceutical development. New York: Ed. Marcel Dekker; 2005.

  15. Breitmaier E. Structure Elucidation by NMR in Organic Chemistry: A Practical Guide. 3rd ed. England: John Wiley & Sons, Ltd.; 2002.




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Rev Cubana Plant Med. 2011;16