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ISSN 0864-4551 (Print)

2012, Number 1

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Biotecnol Apl 2012; 29 (1)

In vitro activity of Surfactant Protein A against Leishmania amazonensis

Lugones Y, Blanco O, Faure R, Monzote L

Language: English
References: 23
Page: 35-37
PDF size: 138.14 Kb.


ABSTRACT

Surfactant protein A (SP-A) is a hydrophilic pulmonary protein belonging to the collectin family, involved in lung homeostasis, the regulation of host defenses and inflammation. The present study addresses the activity of SP-A against promastigotes and amastigotes of Leishmania amazonensis and its cytotoxicity for host cells. SP-A exhibited similar activity against both parasite forms, with an IC50 of 34.0 ± 3.1 and 33.6 ± 1.1 µg/mL against promastigotes and amastigotes, respectively. It was moderately cytotoxic to peritoneal macrophages from BALB/c mice, exhibiting an IC50 value of 172.0 ± 6.1 µg/mL. This is the first report on the anti-leishmanial activity of SP-A.


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