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2011, Number 4

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Rev Mex Med Repro 2011; 3.4 (4)

The value of luteal phase supplementation with estradiol valerianate and progesterone in an assisted reproduction program

Carmona RIO, Santos HR, Galache VP, Hernández AS, Batiza RVA, Díaz SP, Arenas MML

Language: Spanish
References: 7
Page: 182-187
PDF size: 78.36 Kb.


ABSTRACT

Objective: To investigate if the addition of estradiol to progesterone scheme during luteal phase in fresh cycles of assisted reproduction improves outcomes of a program of assisted reproduction.
Patients and method: This study was conducted at the Institute for the Study of Human Conception, in Monterrey, Nuevo Leon, Mexico. Cycles of in vitro fertilization and intracytoplasmic sperm injection with embryo transfer were included from January to December 2009. Patients were divided into two groups according to supplementation of the luteal phase: group I (n = 24), with estradiol valerianate and progesterone, group II (n = 92), only with progesterone supplementation. We analyzed the pregnancy and implantation rates by comparison of means to establish a significant difference in the different groups, and the categorical variables with χ2 test; continuous variables were analyzed with Student’s t-test comparison of means.
Results: The pregnancy rate in group I was 41.6% and in group was 40.2% (p non significant), and the implantation rate was 14.2% for group I and 16.9% for group II (p non significant).
Conclusions: Preliminary results of this study indicated that supplemental progesterone and estradiol during luteal phase do not provide better results than progesterone alone in a program of in vitro fertilization and intracytoplasmic sperm injection with embryo transfer.


REFERENCES

  1. Maslar IA. The progestational endometrium. Semin Reprod Endocrinol 1988;6:115-128.

  2. Ghosh D, Sengupta J. Luteal phase ovarian oestrogen is not essential for implantation and maintenance of pregnancy from surrogate embryo transfer in the rhesus monkey. Hum Reprod 1994;9:639-637.

  3. De Ziegler D. Hormonal control of endometrial receptivity. Hum Reprod 1995;10:4-6.

  4. Kaider AS, Coulam C. Luteal estrogen supplementation in pregnancies associated with low serum estradiol concentrations. Early Pregnancy 2000;4:191-199.

  5. Fatemi HM, Kolibianakis EM, Camus M, Tournaye H, et al. Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum Reprod 2006;21:2628-2632.

  6. Gelbaya T, Kyrgiou M, Tsoumpou I, Nardo L. The use of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection cycles: A systematic review and meta-analysis. Fertil Steril 2008;90(6):2116-2125.

  7. Pritts EA, Atwood AK. Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod 2002;17:2287-2299.




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