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2011, Number 4

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Rev Mex Med Repro 2011; 3.4 (4)

Determinants on the results of intrauterine insemination: analysis of 1,040 consecutive cycles

González CJ, Linder EC, Aguirre RG,Vilchis NP, Smeke BJ, Navarro MC, Rodríguez MJA
Full text How to cite this article

Language: Spanish
References: 10
Page: 193-198
PDF size: 86.18 Kb.


Key words:

assisted reproductive techniques, intrauterine insemination, reproductive success.

ABSTRACT

Background: There are a variety of infertility treatments, however, intrauterine insemination (IUI) is still useful, when compared with more complex techniques.
Objective: To determine factors favoring the reproductive success in patients with diagnosis of infertility who underwent ovulation induction and intrauterine insemination, valuing the success with the percentage of pregnancies with fetal heart rate (+).
Material and method: A retrospective study of 1,040 consecutive cycles of IUI, from January 1998 to December 2004. We included patients undergoing ovulation induction and IUI. We excluded those with incomplete records or who discontinued treatment.
Results: Of 1,040 cycles, pregnancy was achieved in 97 patients. The use of monotherapy for ovulation induction had lower reproductive success. With 4 follicles we obtained a significantly higher proportion of pregnancy, another finding was that patients with higher reproductive success had a higher total numbers of motile sperm post-washing, and we found that the patients with endometriosis had a lower pregnancy rate (31.3% vs 68.6%, p ‹ 0.001).
Conclusions: Intrauterine insemination is a useful, acceptable and accessible technique. The factors favoring the reproductive success are: the use of combined therapy for ovulation induction, the use of 4 follicles, a high number of motile sperm and a etiology of the infertility different from endometriosis.


REFERENCES

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  2. Edwards G, Brody S. Principles and Practice of Assisted Human Reproduction. Philadelphia: WB Saunders Co.; 1995:109-110.

  3. Aranda JE, Alvarez L, Barrón J, Kably Ambe A. Efficacy of a program of insemination with cryopreserved semen as treatment of the male factor. Ginecol Obstet Mex 1997;65:520-522.

  4. Farhi J, Ben A, Lande Y, Fisch B. Role of treatment with ovarian stimulation and intrauterine insemination in women with unilateral tubal occlusion diagnosed by hysterosalpingography. Fertil Steril 2007;88(2):396-400.

  5. Nyboe A, Goossens V, Bhattacharya S, Ferraretti AP, et al. Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European FIV Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod 2009;24(6):1267-1287.

  6. Cantineau AE, Cohlen BJ, Heineman MJ. Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database Syst Rev 2007;18(2):CD005356. Review.

  7. Zeyneloglu HB, Arici A, Olive DL, Duleba AJ. Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins: a meta-analysis. Fertil Steril 1998;69(3):486-491.

  8. Saucedo de la Llata E, Moraga MR, Batiza V, Galache P, et al. Influence of sperm morphology on results of intrauterine insemination. Ginecol Obstet Mex 2003;71:455-459.

  9. Barroso G, Karchmer S, Castelazo E, Carballo E, Kably A. A prospective randomized trial of the impact of misoprostol (PgE1) on pregnancy rate after intrauterine insemination (IUI) therapy: a preliminary report. Ginecol Obstet Mex 2001;69:346-350.

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Rev Mex Med Repro. 2011;3.4