2012, Number 3
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Rev Mex Med Repro 2012; 4.5 (3)
Analysis of NPY-induced hypothalamic nutritional complications in reproduction
Apolinar LM, García DE, Ruiz AM, Damasio SL, Hernández-Valencia M
Language: Spanish
References: 19
Page: 110-115
PDF size: 93.98 Kb.
ABSTRACT
Background: Deregulation in the availability of food in prenatal and postnatal life, predisposes to the development of processes of metabolic and hormonal adaptation that persist throughout life. Thus, in reproducing a state of malnutrition triggers a low birth weight (LBW). Considering that induces changes in the brain, the hypothalamus integrates nutritional signals also participate in the energy balance through hormonal systems such as leptin and neuropeptide Y (NPY).
Objective: Analyze the effect of fetal undernutrition in the expression of NPY1 hypothalamic receptor.
Methods: Sprague Dawley rats were used with food restriction to 50% in pregnancy compared control group (C); was obtained in offspring a low birth weight (LBW group), after weaning were fed high-calorie diet, at 2 and 12 weeks-old with the hypothalamus by RT-PCR was analyzed receptor expression NPY1.
Results: Body weight at birth was lower in the LBW vs control group (p ‹0.001), but at 2 to 12 weeks increased (p ‹0.001), the expression in the hypothalamus NPY1 receptor was higher in group LBW vs C at 2 weeks p ‹0.05.
Conclusions: These results suggest that in the reproduction with presence of malnutrition induced changes to optimize their energy balance, with an increase in expression in hypothalamic NPY1 receptor, generating a hyperphagia when food is available. Possibly secondary to adaptations of catch up growth.
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