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Colegio de Medicina Interna de México.

2012, Number 4

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Med Int Mex 2012; 28 (4)

Hypoalbuminemia as risk factor for bleeding of high digestive tract in patients with Child B hepatic insufficiency

Maldonado LCJ, Jiménez SNG, Sánchez HG

Language: Spanish
References: 13
Page: 319-324
PDF size: 75.98 Kb.


ABSTRACT

Background: In patients with hepatic failure have identified risk factors for upper gastrointestinal bleeding, including Child C liver failure and thrombocytopenia. We’ll seek to determine the association between serum albumin and upper gastrointestinal bleeding in patients with Child-Pugh class B liver failure.
Material and methods: We included patients with Child B liver failure with or without upper gastrointestinal bleeding. Demographic variables were recorded, it was determining blood count, blood chemistry, liver function tests and clotting times. For statistical analysis we used average percentage, standard deviation, Student's t test, χ2, Fisher exact test and Spearman correlation.
Results: A total of 30 patients, 15 in each group. Albumin in the bleeding group had a mean 2.6 ± 0.68 mg/dL, in the other group was 2.7 ± 0.83 mg/dL (p = 0.29). The etiology was alcoholism in 100%. In the group of patients with gastrointestinal bleeding, 26.6% had esophageal varices DaGradi II, 46.6% had DaGradi III, 20% had DaGradi IV and 6.6% had DaGradi V. The odds ratio among patients who presented bleeding and serum albumin ‹ 3 mg/dL was 1.3 (p = 1).
Conclusions: In patients with Child B liver failure, hypoalbuminemia is not associated with bleeding. Variables such as ascites, creatinine and hemoglobin weren´t associated with bleeding.


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