Porrata LF, Markovic SN

Language: English
References: 32
Page: 108-113
PDF size: 436.20 Kb.

ABSTRACT

The therapeutic benefit reported from allogeneic stem cell transplantation is attributed to the graft versus tumor effect produced by the infused donor immune effector cells to eradicate tumor cells. However, the immune response produced by the donor immune effector cells is not specific creating not only the graft versus tumor effect, but also the detrimental effects of graft versus host disease. Recent reports have shown that the infusion of collected "bystander" lymphocytes from the stem cell autograft correlates with lymphocyte recovery and clinical outcomes in patients undergoing autologous stem cell transplantation (ASCT), similar to the graft versus tumor effect seen in the allogeneic stem cell transplantation without the adverse effects of graft versus host disease. The discovery that host immune effector cells collected at the same time as the stem cells can improve clinical outcomes post-ASCT, suggest that autograft can be viewed not only as a therapeutic maneuver to recover bone marrow function after deliver high-dose chemotherapy, but also as an adoptive immunotherapeutic intervention capable of eradicating tumor cells in cancer patients. In this article, we review how to enhance host immune effector cells collection, the different immune effector cells collected and infused from the stem cell autograft, and their association with clinical outcome post-ASCT.

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