Ochoa-Hernández AB, Juárez-Vázquez CI, Mónica Alejandra Rosales-Reynoso, Patricio Barros-Núñez

Language: Spanish
References: 0
Page: 389-398
PDF size: 244.36 Kb.

ABSTRACT

The Wnt-β-catenina signalling pathway plays a crucial role in the regulation, differentiation, proliferation and cellular death processes; consequently, alterations in this pathway are involved in numerous abnormalities of development, growth and homeostasis in animal organisms. Wnt proteins include a numerous family of secretion glycoprotein which joint to Frizzled receptors and Low Density Lipoprotein Receptor-related Protein, in order to stabilize the critical β-catenina protein, and to initiate an intricate signaling cascade, which is related to multiple nucleo-cytoplasmatic processes. Alterations in the canonical Wnt-β-catenina signaling pathway have been associated with variations in a number of proteins participating in this route, or with activation/inactivation of oncogenes and tumor suppressor genes, which explain different processes of tumorigenesis, in addition to a number of malformations and human diseases.
This review describes the ralations between the Wnt-β-catenina signaling pathway with different neoplasic processes, as well as its application in the diagnosis and prognosis of cancer.