2010, Number 4
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Rev Med Inst Mex Seguro Soc 2010; 48 (4)
Thin layer chromatography and infrared spectroscopy in the diagnosis of salicylic intoxication
Rodríguez-Tito JC, Clapé-Laffita O, Marín-Sánchez D, Pérez-Garrido N, Bonne-Hernández R
Language: Spanish
References: 10
Page: 453-456
PDF size: 27.57 Kb.
ABSTRACT
Drugs are the main causal agents in intoxications
with suicide purposes. Salicylates are few frequency
related. In this paper we reported a patient with suspicion
of acute exogenous intoxication with salicylates.
The patient showed clinical symptoms of fever,
hypoglycaemia, low cardiac rhythm, hyperventilation,
pulmonary edema and coma. We employed
analytical toxicology to elucidate the drug involved
in the intoxication, using thin layer chromatography
(TLC) and infrared spectrometry to detect acetyl
salicylic acid, as the cause agent of intoxication clinical
pattern, in acids extracts from urine and gastric
content. The analytical results corresponds with clinical
symptom showed by patient and the information
obtained with the medical monitoring of him.
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