Rivera FN ,Mondragón FR

Language: Spanish
References: 16
Page: 13-18
PDF size: 222.56 Kb.

ABSTRACT

With the rise of incidence of the AIDS-HIV disease, toxoplasmosis has re-emerged and positioned as one the most common opportunistic diseases in the world. Diagnosis of this parasitosis is achieved mainly by immunological methods; recently the technique of the polymease chain reaction (PCR) has been standardized to detect specific parasite´s DNA sequences in blood and tissues of infected patients. Application of pharmacological treatments and vaccines against Toxoplasma has observed a limited advance due to the lack of experimental conditions that allow a successful differentiation from the tachyzoite to the bradyzoite formwith the consecutive induction of cystogenesis in vitro. Efficient induction and successful isolation of enriched preparations with tissue cysts, will allow the characterization of their molecular composition and immunoprotector properties. In addition, it will allow the evaluation and design of drugs able to transverse the cyst wall in order to eliminate the intra-cyst parasites.

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