Domínguez-Hüttinger E, Macías-Silva M

Language: Spanish
References: 24
Page: 53-59
PDF size: 263.54 Kb.

ABSTRACT

”Sloan-Kettering-Institute Like” (skil) is a very interesting gene that has been associated to processes like embryo development, cancer development, immune response and tissue regeneration. Alterations in the expression of SKIL normal levels contribute to tumor development, thus SKIL is considered as both a tumor suppressor and an oncoprotein. The main role of the SKIL protein is to act as a corepressor of the TGF-β signal transduction pathway. SKIL functions as a transcriptional corepressor that inhibits the TGF-β pathway interfering with the transcriptional activity of the main TGF-β effectors, the Smad proteins, and by recruiting corepressors and histone deacetilases. In absence of SKIL, Smads regulate the expression on TGF-β target genes while they act as transcription factors. TGF-β induces the expression of the gene skil, but TGF-β also regulates negatively the protein levels of SKIL by inducing its degradation via ubiquitin-proteasome system. This regulation constitutes a good example of a negative feedback loop present in signal transduction pathways.

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